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Long-Term Survival Outcomes of Elderly Patients Treated With S-1 or Capecitabine Plus Oxaliplatin for Stage II or III Gastric Cancer: A Multicenter Cohort Study

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dc.contributor.author김형일-
dc.date.accessioned2022-05-09T17:18:29Z-
dc.date.available2022-05-09T17:18:29Z-
dc.date.issued2022-03-
dc.identifier.issn2093-582X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188500-
dc.description.abstractPurpose: Tegafur/gimeracil/oteracil (S-1) and capecitabine plus oxaliplatin (CAPOX) are standard adjuvant chemotherapies (ACs) administered after gastrectomy to patients with stage II or III gastric cancer. However, the efficacy of AC in elderly patients remains unclear. The objective of this retrospective multicenter cohort study was to compare the efficacies of S-1 and CAPOX AC in patients aged ≥70 years. Materials and methods: Nine hundred eighty-three patients who were treated with AC using S-1 (768 patients) or CAPOX (215 patients) were enrolled in this study. Each patient underwent AC after curative gastrectomy for stage II or III gastric cancer at one of 27 hospitals in the Republic of Korea between January 2012 and December 2013. Relapse-free survival (RFS) and overall survival (OS) were analyzed according to AC regimen and age group. Results: Of the 983 patients, 254 (25.8%) were elderly. This group had a similar RFS (P=0.099) but significantly poorer OS (p=0.003) compared with the non-elderly group. Subgroup analysis of the non-elderly group revealed no AC-associated differences in survival. Subgroup analysis of the elderly group revealed significantly better survival in the S-1 group than in the CAPOX group (RFS, P<0.001; OS, P<0.001). Multivariate analysis revealed that the CAPOX regimen was an independent poor prognostic factor for RFS (hazard ratio [HR], 1.891; 95% confidence interval [CI], 1.072-3.333; P=0.028) and OS (HR, 2.970; 95% CI, 1.550-5.692; P=0.001). Conclusions: This multicenter observational cohort study found significant differences in RFS and OS between S-1 and CAPOX AC among patients with gastric cancer aged ≥70 years.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Gastric Cancer Association-
dc.relation.isPartOfJOURNAL OF GASTRIC CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleLong-Term Survival Outcomes of Elderly Patients Treated With S-1 or Capecitabine Plus Oxaliplatin for Stage II or III Gastric Cancer: A Multicenter Cohort Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSeohee Choi-
dc.contributor.googleauthorJae-Seok Min-
dc.contributor.googleauthorSang-Ho Jeong-
dc.contributor.googleauthorMoon-Won Yoo-
dc.contributor.googleauthorYoung-Gil Son-
dc.contributor.googleauthorSung Jin Oh-
dc.contributor.googleauthorJong-Han Kim-
dc.contributor.googleauthorJoong-Min Park-
dc.contributor.googleauthorHoon Hur-
dc.contributor.googleauthorYe Seob Jee-
dc.contributor.googleauthorSun-Hwi Hwang-
dc.contributor.googleauthorSung-Ho Jin-
dc.contributor.googleauthorSang Eok Lee-
dc.contributor.googleauthorYoung-Joon Lee-
dc.contributor.googleauthorKyung Won Seo-
dc.contributor.googleauthorSungsoo Park-
dc.contributor.googleauthorChang Min Lee-
dc.contributor.googleauthorChang Hyun Kim-
dc.contributor.googleauthorIn Ho Jeong-
dc.contributor.googleauthorHan Hong Lee-
dc.contributor.googleauthorSung Il Choi-
dc.contributor.googleauthorSang-Il Lee-
dc.contributor.googleauthorChan-Young Kim-
dc.contributor.googleauthorHyundong Chae-
dc.contributor.googleauthorMyoung-Won Son-
dc.contributor.googleauthorKyung Ho Pak-
dc.contributor.googleauthorSungsoo Kim-
dc.contributor.googleauthorMoon-Soo Lee-
dc.contributor.googleauthorHyoung-Il Kim-
dc.identifier.doi10.5230/jgc.2022.22.e6-
dc.contributor.localIdA01154-
dc.relation.journalcodeJ01415-
dc.identifier.eissn2093-5641-
dc.identifier.pmid35425655-
dc.subject.keywordAdjuvant chemotherapy-
dc.subject.keywordElderly-
dc.subject.keywordGastric cancer-
dc.subject.keywordRecurrence-
dc.subject.keywordSurvival-
dc.contributor.alternativeNameKim, Hyoung Il-
dc.contributor.affiliatedAuthor김형일-
dc.citation.volume22-
dc.citation.number1-
dc.citation.startPage67-
dc.citation.endPage77-
dc.identifier.bibliographicCitationJOURNAL OF GASTRIC CANCER, Vol.22(1) : 67-77, 2022-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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