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Reactivity Differences Enable ROS for Selective Ablation of Bacteria

Authors
 Xiaofeng Wu  ;  Mengyao Yang  ;  Ji Seon Kim  ;  Rui Wang  ;  Gyoungmi Kim  ;  Jeongsun Ha  ;  Heejeong Kim  ;  Yejin Cho  ;  Ki Taek Nam  ;  Juyoung Yoon 
Citation
 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol.61(17) : e202200808, 2022-04 
Journal Title
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN
 1433-7851 
Issue Date
2022-04
MeSH
Animals ; Anti-Bacterial Agents / pharmacology ; Bacteria ; Gram-Negative Bacteria ; Gram-Positive Bacteria* ; Mice ; Photochemotherapy* / methods ; Photosensitizing Agents / pharmacology ; Reactive Oxygen Species
Abstract
An effective strategy to engineer selective photodynamic agents to surmount bacterial-infected diseases, especially Gram-positive bacteria remains a great challenge. Herein, we developed two examples of compounds for a proof-of-concept study where reactive differences in reactive oxygen species (ROS) can induce selective ablation of Gram-positive bacteria. Sulfur-replaced phenoxazinium (NBS-N) mainly generates a superoxide anion radical capable of selectively killing Gram-positive bacteria, while selenium-substituted phenoxazinium (NBSe-N) has a higher generation of singlet oxygen that can kill both Gram-positive and Gram-negative bacteria. This difference was further evidenced by bacterial fluorescence imaging and morphological changes. Moreover, NBS-N can also successfully heal the Gram-positive bacteria-infected wounds in mice. We believe that such reactive differences may pave a general way to design selective photodynamic agents for ablating Gram-positive bacteria-infected diseases.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/anie.202200808
DOI
10.1002/anie.202200808
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188498
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