Cited 5 times in
Rheumatoid factor positivity in antineutrophil cytoplasmic antibody-associated vasculitis: a distinct clinical entity or innocent bystander?
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 하장우 | - |
dc.date.accessioned | 2022-05-09T17:11:56Z | - |
dc.date.available | 2022-05-09T17:11:56Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1462-0324 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188433 | - |
dc.description.abstract | Objective: To investigate the significance of RF positivity in ANCA-associated vasculitis (AAV) patients. Methods: AAV patients were divided into groups as follows: RF (+)/ANCA (+) (n = 94), RF (-)/ANCA (+) (n = 80), RF (+)/ANCA (-) (n = 15) and RF (-)/ANCA (-) (n = 25). Their clinical data, organ involvement patterns, laboratory data, and patient outcomes were assessed. Kaplan-Meier analysis and propensity score matching (PSM) were performed to compare outcomes and analyse differences between the groups. Results: Of the 214 patients, RF and ANCA positivity was found in 109 (50.9%) and 174 (81.3%) patients, respectively. RF (+)/ANCA (+) patients more frequently presented with general manifestations (58.5%) than the other groups. Additionally, compared with those of RF (-)/ANCA (+) group, RF (+)/ANCA (+) patients were older, had higher white blood cell, neutrophil, platelet counts and acute phase reactants; however, creatinine and albumin levels were lower. The end-stage kidney disease-free survival rate was significantly higher in the RF (+)/ANCA (+) group (P =0.013), while the proportion of renal involvement was comparable to the RF (-)/ANCA (+) group. PSM showed no difference in patient outcomes between the two groups after adjustment. Conclusion: RF positivity was associated with a distinct phenotype in AAV patients. In particular, difference was observed in clinical features and outcomes between RF (+)/ANCA (+) and RF (-)/ANCA (+) groups, although the direct prognostic implication of RF was not evident. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | RHEUMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / complications | - |
dc.subject.MESH | Antibodies, Antineutrophil Cytoplasmic | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Failure, Chronic* / complications | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Rheumatoid Factor | - |
dc.title | Rheumatoid factor positivity in antineutrophil cytoplasmic antibody-associated vasculitis: a distinct clinical entity or innocent bystander? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Jang Woo Ha | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.identifier.doi | 10.1093/rheumatology/keab595 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A06125 | - |
dc.relation.journalcode | J03672 | - |
dc.identifier.eissn | 1462-0332 | - |
dc.identifier.pmid | 34320628 | - |
dc.identifier.url | https://academic.oup.com/rheumatology/article/61/4/1366/6329840?login=false | - |
dc.subject.keyword | antineutrophil cytoplasmic antibody | - |
dc.subject.keyword | end-stage kidney disease | - |
dc.subject.keyword | general manifestation | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | rheumatoid factor | - |
dc.subject.keyword | vasculitis | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 안성수 | - |
dc.contributor.affiliatedAuthor | 이상원 | - |
dc.contributor.affiliatedAuthor | 하장우 | - |
dc.citation.volume | 61 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1366 | - |
dc.citation.endPage | 1375 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY, Vol.61(4) : 1366-1375, 2022-04 | - |
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