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Effect of the Number of Micro-Osteoperforations on the Rate of Tooth Movement and Periodontal Response in Mice

Authors
 Tselmuun Erdenebat  ;  Dong-Joon Lee  ;  Su-Jung Kim  ;  Yoon Jeong Choi  ;  Eun-Jung Kim  ;  Eun-Hack Choi  ;  Jing Liu  ;  Chung-Ju Hwang  ;  Han-Sung Jung  ;  Jung-Yul Cha 
Citation
 FRONTIERS IN PHYSIOLOGY, Vol.13 : 837094, 2022-03 
Journal Title
FRONTIERS IN PHYSIOLOGY
Issue Date
2022-03
Keywords
bone formation ; cementum ; micro-CT ; micro-osteoperforation ; orthodontic tooth movement ; root resorption
Abstract
Accelerated tooth movement can be achieved using micro-osteoperforations (MOPs) to stimulate regeneration of the alveolar bone during minimally invasive surgical trauma. However, there is currently no standardized protocol and limited reports regarding the side effects of MOPs based on biological evidence. This study sought to evaluate the biological effects of the number of MOPs on orthodontic tooth movement (OTM) and the potential risk for root resorption. Male CD1 mice were divided into 4 groups based on the number of MOPs, as follows: Sham; 0MOP+OTM; 2MOP+OTM; and 4MOP+OTM groups. Tooth movement distance and the number of osteoclasts were higher whereas bone volume and trabecular number were lower in the 4MOP+OTM group compared to those of the 0MOP+OTM group. Immunofluorescent assay analysis indicated that the 4MOP+OTM group was positively associated with rapid cementum regeneration and periodontal ligament tissue formation. Our findings revealed that the MOP procedure affected tooth movement and did not significantly contribute to root resorption, whereas it may promote constitutive activation of cementogenesis.
Files in This Item:
T202200970.pdf Download
DOI
10.3389/fphys.2022.837094
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kim, Eun-Jung(김은정) ORCID logo https://orcid.org/0000-0002-9515-7590
Lee, Dong Joon(이동준) ORCID logo https://orcid.org/0000-0001-6532-9729
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cha, Jung Yul(차정열)
Choi, Yoon Jeong(최윤정) ORCID logo https://orcid.org/0000-0003-0781-8836
Hwang, Chung Ju(황충주) ORCID logo https://orcid.org/0000-0003-3024-4551
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188366
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