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Propofol prevents further prolongation of QT interval during liver transplantation

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dc.contributor.author구본녀-
dc.contributor.author김승현-
dc.contributor.author이재근-
dc.contributor.author주향미-
dc.contributor.author최수연-
dc.date.accessioned2022-05-09T17:04:08Z-
dc.date.available2022-05-09T17:04:08Z-
dc.date.issued2022-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188362-
dc.description.abstractHere, we aimed to compare the effects of two anesthetic methods (desflurane inhalation anesthesia vs. propofol-based total intravenous anesthesia (TIVA)] on corrected QT interval (QTc) values during living donor liver transplantation. Altogether, 120 patients who underwent living donor liver transplantation were randomized to either the desflurane or TIVA group. The primary outcome was intraoperative QTc change. Other electrocardiogram, hemodynamic findings and postoperative outcomes were examined as secondary outcomes. QTc values were prolonged intraoperatively in both groups; however, the change was smaller in the TIVA group than in the desflurane group (PGroup × Time < 0.001). More patients had QTc values of > 500 ms in the desflurane group than in the TIVA group (63.3% vs. 28.3%, P < 0.001). In patients with preoperative QTc prolongation, QTc was further prolonged in the desflurane group, but not in the TIVA group (PGroup × Time < 0.001). Intraoperative norepinephrine and vasopressin use were higher in the desflurane group than in the TIVA group. Propofol-based TIVA may reduce QTc prolongation during living donor liver transplantation compared to that observed with desflurane inhalational anesthesia, particularly in patients with preoperative QTc prolongation. Additionally, patients managed with propofol-based TIVA required less vasopressor during the procedure as compared with those managed with desflurane inhalational anesthesia.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnesthetics, Inhalation* / adverse effects-
dc.subject.MESHAnesthetics, Intravenous / adverse effects-
dc.subject.MESHDesflurane-
dc.subject.MESHHumans-
dc.subject.MESHLiver Transplantation* / adverse effects-
dc.subject.MESHLiving Donors-
dc.subject.MESHLong QT Syndrome*-
dc.subject.MESHPropofol* / adverse effects-
dc.titlePropofol prevents further prolongation of QT interval during liver transplantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorSeung Hyun Kim-
dc.contributor.googleauthorJae Geun Lee-
dc.contributor.googleauthorHyang Mi Ju-
dc.contributor.googleauthorSuYoun Choi-
dc.contributor.googleauthorHyukjin Yang-
dc.contributor.googleauthorBon-Nyeo Koo-
dc.identifier.doi10.1038/s41598-022-08592-4-
dc.contributor.localIdA00193-
dc.contributor.localIdA05098-
dc.contributor.localIdA03068-
dc.contributor.localIdA06060-
dc.contributor.localIdA05732-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid35301381-
dc.contributor.alternativeNameKu, Bon Nyo-
dc.contributor.affiliatedAuthor구본녀-
dc.contributor.affiliatedAuthor김승현-
dc.contributor.affiliatedAuthor이재근-
dc.contributor.affiliatedAuthor주향미-
dc.contributor.affiliatedAuthor최수연-
dc.citation.volume12-
dc.citation.number1-
dc.citation.startPage4636-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.12(1) : 4636, 2022-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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