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Review of Allogeneic Dentin Graft for Maxillofacial Bone Defects

Authors
 Jeong-Kui Ku  ;  Yeong Kon Jeong  ;  In-Woong Um 
Citation
 TISSUE ENGINEERING PART C-METHODS, Vol.27(8) : 472-480, 2021-08 
Journal Title
TISSUE ENGINEERING PART C-METHODS
ISSN
 1937-3384 
Issue Date
2021-08
MeSH
Bone Regeneration ; Dentin* ; Hematopoietic Stem Cell Transplantation* ; Humans
Keywords
allogeneic graft ; antigenicity ; demineralized dentin matrix ; osteoinductivity ; review
Abstract
Although autogenous demineralized dentin matrix (auto-DDM) has shown promising clinical and histological results, it has certain limitations beyond its osteoinductivity and osteoconductivity. Therefore, the application of dentin graft material from other individuals-allogeneic DDM (allo-DDM)-has been considered an alternative to auto-DDM. However, few studies have investigated the osteoinductivity and antigenicity of allo-DDM. Herein, we reviewed all human studies related to allogeneic dentin application for the management of maxillofacial bone defects. Clinical studies have shown the osteoinductivity of allo-DDM in extraskeletal and skeletal sites, regardless of occasional antigenicity. Impact statement Although autogenous demineralized dentin matrix (auto-DDM) has shown promising clinical and histological results, it has certain limitations beyond its proven osteoinductivity and osteoconductivity. Therefore, the application of dentin graft material from other individuals-allogeneic DDM (allo-DDM)-has been considered as an alternative to auto-DDM. However, few studies have investigated the osteoinductivity and antigenicity of allo-DDM. This is the first review of all human studies related to allogeneic dentin grafts for the management of maxillofacial bone defects. Clinical studies have shown the osteoinductivity of allo-DDM in extraskeletal and skeletal sites, regardless of occasional antigenicity.
Full Text
https://www.liebertpub.com/doi/10.1089/ten.TEC.2021.0152
DOI
10.1089/ten.TEC.2021.0152
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Jeong-Kui(구정귀) ORCID logo https://orcid.org/0000-0003-1192-7066
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188239
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