Cited 9 times in
Analysis of the Molecular Signature of Breast Implant-Associated Anaplastic Large Cell Lymphoma in an Asian Patient
DC Field | Value | Language |
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dc.contributor.author | 이충근 | - |
dc.date.accessioned | 2022-05-09T16:45:47Z | - |
dc.date.available | 2022-05-09T16:45:47Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1090-820X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188180 | - |
dc.description.abstract | Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL)-a new category of anaplastic large cell lymphoma associated with textured breast implants-has a distinct variation in incidence and is especially rare in Asia. We report the first case of BIA-ALCL in Korea and present its histological and genetic characteristics. A 44-year-old female patient presented with a typical clinical course and symptoms, including breast augmentation with textured breast implants, late-onset peri-implant effusion, and CD30+ALK- histology, followed by bilateral implant removal and total capsulectomy. For histological analysis, we performed immunohistochemistry of the bilateral breast capsules. For transcriptome analysis, we identified highly upregulated gene sets employing RNA-sequencing and characterized the lymphoma immune cell components. In the lymphoma-associated capsule, CD30+ cells infiltrated not only the lymphoma lesion but also the peritumoral lesion. The morphologies of the myofibroblasts and vessels in the peritumoral lesion were similar to those in the tumoral lesion. We observed strong activation of the JAK/STAT3 pathway and expression of programmed death ligand-1 in the lymphoma. Unlike the molecular profiles of BIA-ALCL samples from Caucasian patients-all of which contained activated CD4+ T cells-the Asian patient's profile was characterized by more abundant CD8+ T cells. This study contributes to a better understanding of the pathogenesis and molecular mechanisms of BIA-ALCL in Asian patients that will ultimately facilitate the development of clinical therapies. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | AESTHETIC SURGERY JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asia | - |
dc.subject.MESH | Breast Implantation* / adverse effects | - |
dc.subject.MESH | Breast Implants* / adverse effects | - |
dc.subject.MESH | Breast Neoplasms* / genetics | - |
dc.subject.MESH | Breast Neoplasms* / surgery | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphoma, Large-Cell, Anaplastic* / etiology | - |
dc.subject.MESH | Lymphoma, Large-Cell, Anaplastic* / genetics | - |
dc.subject.MESH | Republic of Korea | - |
dc.title | Analysis of the Molecular Signature of Breast Implant-Associated Anaplastic Large Cell Lymphoma in an Asian Patient | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Il-Kug Kim | - |
dc.contributor.googleauthor | Ki Yong Hong | - |
dc.contributor.googleauthor | Choong-Kun Lee | - |
dc.contributor.googleauthor | Bong Gyu Choi | - |
dc.contributor.googleauthor | Hyunjong Shin | - |
dc.contributor.googleauthor | Jun Ho Lee | - |
dc.contributor.googleauthor | Min Kyoung Kim | - |
dc.contributor.googleauthor | Mi Jin Gu | - |
dc.contributor.googleauthor | Jung Eun Choi | - |
dc.contributor.googleauthor | Tae Gon Kim | - |
dc.identifier.doi | 10.1093/asj/sjaa398 | - |
dc.contributor.localId | A03259 | - |
dc.relation.journalcode | J00051 | - |
dc.identifier.eissn | 1527-330X | - |
dc.identifier.pmid | 33367520 | - |
dc.contributor.alternativeName | Lee, Choong-kun | - |
dc.contributor.affiliatedAuthor | 이충근 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | NP214 | - |
dc.citation.endPage | NP222 | - |
dc.identifier.bibliographicCitation | AESTHETIC SURGERY JOURNAL, Vol.41(5) : NP214-NP222, 2021-04 | - |
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