Cited 4 times in

Intraventricular hemorrhage clot clearance rate as an outcome predictor in patients with aneurysmal subarachnoid hemorrhage: A retrospective study

DC Field Value Language
dc.contributor.author박근영-
dc.contributor.author이재환-
dc.contributor.author장창기-
dc.contributor.author정준호-
dc.date.accessioned2022-05-09T16:44:29Z-
dc.date.available2022-05-09T16:44:29Z-
dc.date.issued2021-12-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188167-
dc.description.abstractBackground: The development of intraventricular hemorrhage (IVH) in aneurysmal subarachnoid hemorrhage (aSAH) is linked with higher mortality and poor neurological recovery. Previous studies have investigated the effect of the amount and distribution of the initial IVH on the prognosis of aSAH. However, no studies have assessed the relationship between the changes in IVH over time and the prognosis of aSAH. The aim of this study was to analyze the effect of the clearance rate of IVH, which can be represented by the IVH clot clearance rate (CCR), on the outcomes of aSAH. Methods: The IVH CCR was calculated based on the difference between the initial and follow-up modified Graeb scores (mGS), which were assessed by initial and 7-day follow-up brain computed tomography, respectively. Poor functional outcome was defined as a modified Rankin Scale score of 3-6. Univariate and multivariable analyses were performed to assess the relationships between IVH CCR and other risk factors and the prognosis of patients. Receiver operating characteristic curve analysis was performed to identify cut-off values of IVH CCR for predicting poor functional outcome. Results: In total, 196 consecutive patients were diagnosed with aSAH between January 2014 and March 2018. According to the inclusion and exclusion criteria, 67 patients were finally included in the study. The univariate analysis revealed that a lower IVH CCR (p<0.001), higher initial mGS (p<0.001), older age (p<0.001), higher initial Hunt and Hess grade (p<0.001), presence of delayed infarction (p=0.03), and presence of shunt-dependent hydrocephalus (p=0.004) were significantly related to poor functional outcome. The multivariable analysis revealed that IVH CCR (odds ratio [OR] 0.941; p=0.029), initial mGS (OR 1.632; p=0.043), age (OR 1.561; p=0.007), initial Hunt and Hess grade (OR 227.296; p=0.030), and delayed infarction (OR 5310.632; p=0.023) were independent predictors of poor functional outcome. Optimal cut-off values of IVH CCR and mGS for poor outcome were 36.27%, and 13.5, respectively (all p< 0.001). Conclusions: The IVH CCR might have an important predictive value on poor functional outcome in patients with aSAH and IVH, along with initial mGS, age, initial Hunt and Hess grade, and delayed infarction.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHCerebral Hemorrhage-
dc.subject.MESHHumans-
dc.subject.MESHHydrocephalus*-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSubarachnoid Hemorrhage* / complications-
dc.subject.MESHSubarachnoid Hemorrhage* / diagnostic imaging-
dc.titleIntraventricular hemorrhage clot clearance rate as an outcome predictor in patients with aneurysmal subarachnoid hemorrhage: A retrospective study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorHae Gi Park-
dc.contributor.googleauthorSunghan Kim-
dc.contributor.googleauthorJoonho Chung-
dc.contributor.googleauthorChang Ki Jang-
dc.contributor.googleauthorKeun Young Park-
dc.contributor.googleauthorJae Whan Lee-
dc.identifier.doi10.1186/s12883-021-02505-0-
dc.contributor.localIdA01442-
dc.contributor.localIdA03088-
dc.contributor.localIdA04794-
dc.contributor.localIdA03731-
dc.relation.journalcodeJ00368-
dc.identifier.eissn1471-2377-
dc.identifier.pmid34893025-
dc.subject.keywordaneurysmal subarachnoid hemorrhage-
dc.subject.keywordcerebral intraventricular hemorrhage-
dc.subject.keywordclot clearance rate-
dc.subject.keywordmodified Graeb score-
dc.subject.keywordpatient outcomes assessment-
dc.contributor.alternativeNamePark, Keun Young-
dc.contributor.affiliatedAuthor박근영-
dc.contributor.affiliatedAuthor이재환-
dc.contributor.affiliatedAuthor장창기-
dc.contributor.affiliatedAuthor정준호-
dc.citation.volume21-
dc.citation.number1-
dc.citation.startPage482-
dc.identifier.bibliographicCitationBMC NEUROLOGY, Vol.21(1) : 482, 2021-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.