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Si Isotope-Enriched Silicon Nanoparticles for an Efficient Hyperpolarized Magnetic Resonance Imaging Probe

Authors
 Jiwon Kim  ;  Donghyuk Jo  ;  Seung-Hyun Yang  ;  Chan-Gyu Joo  ;  Nicholas Whiting  ;  Shivanand Pudakalakatti  ;  Hyeonglim Seo  ;  Hye Young Son  ;  Sun-Joon Min  ;  Pratip Bhattacharya  ;  Yong-Min Huh  ;  Jeong Hyun Shim  ;  Youngbok Lee 
Citation
 ACS APPLIED MATERIALS & INTERFACES, Vol.13(48) : 56923-56930, 2021-12 
Journal Title
ACS APPLIED MATERIALS & INTERFACES
ISSN
 1944-8244 
Issue Date
2021-12
MeSH
Animals ; Biomimetic Materials / administration & dosage ; Biomimetic Materials / chemical synthesis ; Biomimetic Materials / chemistry* ; Contrast Media / administration & dosage ; Contrast Media / chemical synthesis ; Contrast Media / chemistry* ; Isotopes ; Magnetic Resonance Imaging* ; Male ; Materials Testing ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nanoparticles / administration & dosage ; Nanoparticles / chemistry* ; Particle Size ; Phantom Limb / diagnostic imaging* ; Porosity ; Silicon / administration & dosage ; Silicon / chemistry*
Keywords
hyperpolarization ; isotope enrichment ; magnetic resonance imaging ; nanoimaging ; silicon nanoparticles
Abstract
Silicon particles have garnered attention as promising biomedical probes for hyperpolarized 29Si magnetic resonance imaging and spectroscopy. However, due to the limited levels of hyperpolarization for nanosized silicon particles, microscale silicon particles have primarily been the focus of dynamic nuclear polarization (DNP) applications, including in vivo magnetic resonance imaging (MRI). To address these current challenges, we developed a facile synthetic method for partially 29Si-enriched porous silicon nanoparticles (NPs) (160 nm) and examined their usability in hyperpolarized 29Si MRI agents with enhanced signals in spectroscopy and imaging. Hyperpolarization characteristics, such as the build-up constant, the depolarization time (T1), and the overall enhancement of the 29Si-enriched silicon NPs (10 and 15%), were thoroughly investigated and compared with those of a naturally abundant NP (4.7%). During optimal DNP conditions, the 15% enriched silicon NPs showed more than 16-fold higher enhancements─far beyond the enrichment ratio─than the naturally abundant sample, further improving the signal-to-noise ratio in in vivo 29Si MRI. The 29Si-enriched porous silicon NPs used in this work are potentially capable to serve as drug-delivery vehicles in addition to hyperpolarized 29Si in vivo, further enabling their potential future applicability as a theragnostic platform.
Full Text
https://pubs.acs.org/doi/10.1021/acsami.1c16617
DOI
10.1021/acsami.1c16617
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Son, Hye Yeong(손혜영) ORCID logo https://orcid.org/0000-0001-5977-6784
Yang, Seung Hyun(양승현) ORCID logo https://orcid.org/0000-0002-0909-7828
Joo, Chan Gyu(주찬규) ORCID logo https://orcid.org/0000-0002-1415-9245
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188146
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