Cited 13 times in
Super-resolution imaging reveals cytoskeleton-dependent organelle rearrangement within platelets at intermediate stages of maturation
DC Field | Value | Language |
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dc.contributor.author | 송재우 | - |
dc.date.accessioned | 2022-05-09T16:42:11Z | - |
dc.date.available | 2022-05-09T16:42:11Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0969-2126 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188144 | - |
dc.description.abstract | A steady supply of platelets maintains their levels in the blood, and this is achieved by the generation of progeny from platelet intermediates. Using systematic super-resolution microscopy, we examine the ultrastructural organization of various organelles in different platelet intermediates to understand the mechanism of organelle redistribution and sorting in platelet intermediate maturation as the early step of platelet progeny production. We observe the dynamic interconversion between the intermediates and find that microtubules are responsible for controlling the overall shape of platelet intermediates. Super-resolution images show that most of the organelles are located near the cell periphery in oval preplatelets and confined to the bulbous tips in proplatelets. We also find that the distribution of the dense tubular system and α granules is regulated by actin, whereas that of mitochondria and dense granules is governed by microtubules. Altogether, our results call for a reassessment of organelle redistribution in platelet intermediates. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | STRUCTURE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Actins / chemistry* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Blood Platelets / ultrastructure* | - |
dc.subject.MESH | Cell Movement | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microscopy, Electron, Transmission | - |
dc.subject.MESH | Microscopy, Fluorescence | - |
dc.subject.MESH | Microtubules / ultrastructure* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Stochastic Processes | - |
dc.subject.MESH | Young Adult | - |
dc.title | Super-resolution imaging reveals cytoskeleton-dependent organelle rearrangement within platelets at intermediate stages of maturation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Seokran Go | - |
dc.contributor.googleauthor | Dokyung Jeong | - |
dc.contributor.googleauthor | Jinkyoung Chung | - |
dc.contributor.googleauthor | Geun-Ho Kim | - |
dc.contributor.googleauthor | Jaewoo Song | - |
dc.contributor.googleauthor | Eunyoung Moon | - |
dc.contributor.googleauthor | Yang Hoon Huh | - |
dc.contributor.googleauthor | Doory Kim | - |
dc.identifier.doi | 10.1016/j.str.2021.06.001 | - |
dc.contributor.localId | A02054 | - |
dc.relation.journalcode | J02691 | - |
dc.identifier.eissn | 1878-4186 | - |
dc.identifier.pmid | 34143977 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0969212621002057 | - |
dc.subject.keyword | cytoskeleton | - |
dc.subject.keyword | platelet intermediate | - |
dc.subject.keyword | platelet progeny | - |
dc.subject.keyword | stochastic optical reconstruction microscopy (STORM) | - |
dc.subject.keyword | super-resolution imaging | - |
dc.contributor.alternativeName | Song, Jae Woo | - |
dc.contributor.affiliatedAuthor | 송재우 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 810 | - |
dc.citation.endPage | 822.e3 | - |
dc.identifier.bibliographicCitation | STRUCTURE, Vol.29(8) : 810-822.e3, 2021-08 | - |
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