Cited 25 times in
Clinical Performance of the Standard Q COVID-19 Rapid Antigen Test and Simulation of its Real-World Application in Korea
DC Field | Value | Language |
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dc.contributor.author | 홍기호 | - |
dc.contributor.author | 이혁민 | - |
dc.date.accessioned | 2022-04-07T05:02:24Z | - |
dc.date.available | 2022-04-07T05:02:24Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188117 | - |
dc.description.abstract | The rapid antigen test (RAT) for coronavirus disease (COVID-19) represents a potent diagnostic method in situations of limited molecular testing resources. However, considerable performance variance has been reported with the RAT. We evaluated the clinical performance of Standard Q COVID-19 RAT (SQ-RAT; SD Biosensor, Suwon, Korea), the first RAT approved by the Korean Ministry of Food and Drug Safety. In total, 680 nasopharyngeal swabs previously tested using real-time reverse-transcription PCR (rRT-PCR) were retested using SQ-RAT. The clinical sensitivity of SQ-RAT relative to that of rRT-PCR was 28.7% for all specimens and was 81.4% for specimens with RNA-dependent RNA polymerase gene (RdRp) threshold cycle (Ct) values ≤23.37, which is the limit of detection of SQ-RAT. The specificity was 100%. The clinical sensitivity of SQ-RAT for COVID-19 diagnosis was assessed based on the Ct distribution at diagnosis of 33,294 COVID-19 cases in Korea extracted from the laboratory surveillance system of Korean Society for Laboratory Medicine. The clinical sensitivity of SQ-RAT for COVID-19 diagnosis in the Korean population was 41.8%. Considering the molecular testing capacity in Korea, use of the RAT for COVID-19 diagnosis appears to be limited. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Society for Laboratory Medicine | - |
dc.relation.isPartOf | ANNALS OF LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | COVID-19 / diagnosis* | - |
dc.subject.MESH | COVID-19 / virology | - |
dc.subject.MESH | COVID-19 Testing / methods | - |
dc.subject.MESH | Humans Nasopharynx / virology | - |
dc.subject.MESH | RNA, Viral / analysis | - |
dc.subject.MESH | RNA, Viral / metabolism | - |
dc.subject.MESH | RNA-Dependent RNA Polymerase / genetics* | - |
dc.subject.MESH | Real-Time Polymerase Chain Reaction | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | SARS-CoV-2 / genetics* | - |
dc.subject.MESH | SARS-CoV-2 / isolation & purification | - |
dc.title | Clinical Performance of the Standard Q COVID-19 Rapid Antigen Test and Simulation of its Real-World Application in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Jaehyeon Lee | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | Hee Jae Huh | - |
dc.contributor.googleauthor | Namsu Kim | - |
dc.contributor.googleauthor | Heungsup Sung | - |
dc.contributor.googleauthor | Hyukmin Lee | - |
dc.contributor.googleauthor | Kyoung Ho Roh | - |
dc.contributor.googleauthor | Taek Soo Kim | - |
dc.contributor.googleauthor | Ki Ho Hong | - |
dc.identifier.doi | 10.3343/alm.2021.41.6.588 | - |
dc.contributor.localId | A06207 | - |
dc.contributor.localId | A03286 | - |
dc.contributor.localId | A01418 | - |
dc.relation.journalcode | J00164 | - |
dc.identifier.eissn | 2234-3814 | - |
dc.identifier.pmid | 34108286 | - |
dc.subject.keyword | Coronavirus disease | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | Laboratory surveillance | - |
dc.subject.keyword | Rapid antigen test | - |
dc.subject.keyword | Real-time reverse-transcription PCR | - |
dc.contributor.alternativeName | Hong, Ki Ho | - |
dc.contributor.affiliatedAuthor | 홍기호 | - |
dc.contributor.affiliatedAuthor | 이혁민 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 588 | - |
dc.citation.endPage | 592 | - |
dc.identifier.bibliographicCitation | ANNALS OF LABORATORY MEDICINE, Vol.41(6) : 588-592, 2021-11 | - |
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