0 106

Cited 0 times in

Association of periodontitis with microvascular complications of diabetes mellitus: A nationwide cohort study

Authors
 Moo-Seok Park  ;  Jimin Jeon  ;  Tae-Jin Song  ;  Jinkwon Kim 
Citation
 JOURNAL OF DIABETES AND ITS COMPLICATIONS, Vol.36(2) : 108107, 2022-02 
Journal Title
JOURNAL OF DIABETES AND ITS COMPLICATIONS
ISSN
 1056-8727 
Issue Date
2022-02
Keywords
Diabetes mellitus ; Microvascular complications ; Oral hygiene ; Periodontitis
Abstract
Background: Periodontitis is a common chronic inflammatory disease and one of oral complications in diabetes. Diabetes-related microvascular complications and periodontitis are also closely related to systemic inflammation. We hypothesized that periodontitis and oral hygiene markers might increase the risk of microvascular complications in diabetes mellitus.

Methods: We enrolled 11,353 diabetes participants without prior microvascular complications who received complete oral health checkups in the National Health Insurance Service-National Health Screening Cohort in 2003-2004. The primary outcome was the first development of diabetes-related microvascular complications, including nephropathy, neuropathy, and retinopathy.

Results: The age of all participants was 55.27 ± 9.46 years, and 7833 (68.99%) participants were male. Periodontitis was noted in 8.37%. During the 7.03 ± 4.30 year of the mean follow-up period, 7227 patients experienced diabetes-related microvascular complications (2645 with nephropathy, 2513 with neuropathy, 2069 with retinopathy). Multivariable Cox regression analyses revealed that periodontitis was an independent risk factor for diabetes-related microvascular complications (adjusted hazard ratio (HR):1.13; 95% confidence interval (CI):1.04-1.23; p = 0.004). In the secondary analysis for individual microvascular complications, periodontitis was an independent risk factor for retinopathy (adjusted HR: 1.21; 95% CI: 1.04-1.40; p = 0.013).

Conclusions: The presence of periodontitis was associated with an increased risk of microvascular complications in diabetes patients.
Full Text
https://www.sciencedirect.com/science/article/pii/S1056872721003317
DOI
10.1016/j.jdiacomp.2021.108107
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188106
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links