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Aggravation of Enlarged Perivascular Spaces in the Centrum Semiovale of Patients with Aneurysmal Subarachnoid Hemorrhage

Authors
 Jina Kim  ;  Bio Joo  ;  Jin Woo Kim  ;  Mina Park  ;  Sung Jun Ahn  ;  Sang Kyu Park  ;  Sang Hyun Suh 
Citation
 CLINICAL NEURORADIOLOGY, Vol.32(1) : 79-87, 2022-03 
Journal Title
CLINICAL NEURORADIOLOGY
ISSN
 1869-1439 
Issue Date
2022-03
MeSH
Basal Ganglia / diagnostic imaging ; Corpus Callosum ; Humans ; Magnetic Resonance Imaging ; Retrospective Studies ; Subarachnoid Hemorrhage* / diagnostic imaging ; Subarachnoid Hemorrhage* / pathology
Keywords
Glymphatic system ; Magnetic resonance imaging ; Ruptured aneurysm ; Stroke ; Virchow-Robin space
Abstract
Purpose: This study aimed to investigate whether enlarged perivascular spaces (ePVS) within the basal ganglia (BG) or centrum semiovale (CSO) aggravate in patients with aneurysmal subarachnoid hemorrhage (aSAH).

Methods: We retrospectively evaluated 139 patients who had undergone brain magnetic resonance imaging (MRI) within 1 month of aSAH occurrence from January 2007 to November 2018. Follow-up brain MRI of 99 patients were available. We scored ePVS in the BG and CSO on a score of 0-4 (0 = no ePVS, 4 ≥ 40 ePVS) on initial and follow-up T2-weighted MRI. Aggravation of ePVS was defined as an ePVS score increase of ≥ 1 on follow-up MRI compared to the initial score. We compared the characteristics between patients with and without aggravation of ePVS and investigated associated variables using logistic regression.

Results: Aggravation of ePVS in the CSO and BG was noted in 31 (31.3%) and 6 (6.1%) patients, respectively. After adjusting for age, sex, and the MRI follow-up period, aggravation of ePVS in the CSO was independently associated with a high Fisher grade (p = 0.007) and high burden of initial ePVS in the CSO (p = 0.049).

Conclusion: Aggravation of ePVS, particularly those in the CSO, had occurred in the long-term follow-up of aSAH patients. This was independently associated with a high burden of aSAH. The amount of subarachnoid blood might have aggravated the drainage of interstitial fluid through glymphatic dysfunction.
Full Text
https://link.springer.com/article/10.1007/s00062-021-01098-y
DOI
10.1007/s00062-021-01098-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Woo(김진우) ORCID logo https://orcid.org/0000-0003-3155-0569
Park, Mina(박미나) ORCID logo https://orcid.org/0000-0002-2005-7560
Park, Sang Kyu(박상규)
Suh, Sang Hyun(서상현) ORCID logo https://orcid.org/0000-0002-7098-4901
Ahn, Sung Jun(안성준) ORCID logo https://orcid.org/0000-0003-0075-2432
Joo, Bio(주비오) ORCID logo https://orcid.org/0000-0001-7460-1421
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188105
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