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Renal Tubular Damage Marker, Urinary N-acetyl-β-D-Glucosaminidase, as a Predictive Marker of Hepatic Fibrosis in Type 2 Diabetes Mellitus

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dc.contributor.author강은석-
dc.contributor.author김혜경-
dc.contributor.author이민영-
dc.contributor.author이병완-
dc.contributor.author이용호-
dc.contributor.author차봉수-
dc.date.accessioned2022-03-11T11:00:08Z-
dc.date.available2022-03-11T11:00:08Z-
dc.date.issued2022-01-
dc.identifier.issn2233-6079-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188094-
dc.description.abstractBackground: Non-alcoholic steatohepatitis is closely associated with the progression of diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM). We investigated whether urinary N-acetyl-β-D-glucosaminidase (u-NAG), an early renal tubular damage biomarker in DKD, could be related to the degree of hepatic fibrosis in patients with T2DM. Methods: A total of 300 patients with T2DM were enrolled in this study. Hepatic steatosis and fibrosis were determined using transient elastography. The levels of urinary biomarkers, including u-NAG, albumin, protein, and creatinine, and glucometabolic parameters were measured. Results: Based on the median value of the u-NAG to creatinine ratio (u-NCR), subjects were divided into low and high u-NCR groups. The high u-NCR group showed a significantly longer duration of diabetes, worsened hyperglycemia, and a more enhanced hepatic fibrosis index. A higher u-NCR was associated with a greater odds ratio for the risk of higher hepatic fibrosis stage (F2: odds ratio, 1.99; 95% confidence interval [CI], 1.04 to 3.82). Also, u-NCR was an independent predictive marker for more advanced hepatic fibrosis, even after adjusting for several confounding factors (β=1.58, P<0.01). Conclusion: The elevation of u-NAG was independently associated with a higher degree of hepatic fibrosis in patients with T2DM. Considering the common metabolic milieu of renal and hepatic fibrosis in T2DM, the potential use of u-NAG as an effective urinary biomarker reflecting hepatic fibrosis in T2DM needs to be validated in the future.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Diabetes Association-
dc.relation.isPartOfDIABETES & METABOLISM JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAcetylglucosaminidase / urine-
dc.subject.MESHBiomarkers-
dc.subject.MESHDiabetes Mellitus, Type 2* / complications-
dc.subject.MESHDiabetes Mellitus, Type 2* / urine-
dc.subject.MESHDiabetic Nephropathies* / diagnosis-
dc.subject.MESHDiabetic Nephropathies* / etiology-
dc.subject.MESHHumans-
dc.subject.MESHLiver Cirrhosis / complications-
dc.subject.MESHLiver Cirrhosis / diagnosis-
dc.titleRenal Tubular Damage Marker, Urinary N-acetyl-β-D-Glucosaminidase, as a Predictive Marker of Hepatic Fibrosis in Type 2 Diabetes Mellitus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHae Kyung Kim-
dc.contributor.googleauthorMinyoung Lee-
dc.contributor.googleauthorYong-Ho Lee-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorBong-Soo Cha-
dc.contributor.googleauthorByung-Wan Lee-
dc.identifier.doi10.4093/dmj.2020.0273-
dc.contributor.localIdA00068-
dc.contributor.localIdA06167-
dc.contributor.localIdA05491-
dc.contributor.localIdA02796-
dc.contributor.localIdA02989-
dc.contributor.localIdA03996-
dc.relation.journalcodeJ00720-
dc.identifier.eissn2233-6087-
dc.identifier.pmid34253010-
dc.subject.keywordAcetylglucosaminidase-
dc.subject.keywordDiabetes mellitus, type 2-
dc.subject.keywordLiver cirrhosis-
dc.subject.keywordNon-alcoholic fatty liver disease-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.affiliatedAuthor강은석-
dc.contributor.affiliatedAuthor김혜경-
dc.contributor.affiliatedAuthor이민영-
dc.contributor.affiliatedAuthor이병완-
dc.contributor.affiliatedAuthor이용호-
dc.contributor.affiliatedAuthor차봉수-
dc.citation.volume46-
dc.citation.number1-
dc.citation.startPage104-
dc.citation.endPage116-
dc.identifier.bibliographicCitationDIABETES & METABOLISM JOURNAL, Vol.46(1) : 104-116, 2022-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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