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Impact of interankle blood pressure difference on major adverse cardiovascular events in cryptogenic stroke patients without peripheral artery disease: a retrospective cohort study

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dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author백민렬-
dc.contributor.author허지회-
dc.contributor.author박은정-
dc.date.accessioned2022-03-11T11:00:00Z-
dc.date.available2022-03-11T11:00:00Z-
dc.date.issued2022-02-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188093-
dc.description.abstractObjective: We investigated whether interankle blood pressure difference (IAND) can predict major adverse cardiovascular events (MACEs) in patients with cryptogenic stroke (CS) without peripheral artery disease (PAD). Design: A retrospective cohort study. Setting: Retrospective medical record data of patients with first-ever acute cerebral infarction who were admitted between 1 January 2007 and 31 July 2013. Participants: CS patients admitted within 7 days of symptom onset were included. Outcome measures: MACEs were defined as stroke recurrence, myocardial infarction occurrence, or death. Survival analyses were conducted using the Kaplan-Meier method and Cox regression analysis. Methods: Consecutive CS patients without PAD who underwent ankle-brachial index (ABI) measurements were enrolled. PAD was defined if a patient had an ABI of <0.90 or a history of angiographically confirmed PAD. Systolic and diastolic IANDs were calculated as follows: right ankle blood pressure-left ankle blood pressure. Results: A total of 612 patients were enrolled and followed up for a median 2.6 (interquartile range, 1.0-4.3) years. In the Cox regression analysis, systolic and diastolic IANDs ≥15 mm Hg were independently associated with MACEs in CS patients without PAD (hazard ratio (HR) 2.115, 95% confidence interval (CI) 1.230 to 3.635 and HR 2.523, 95% CI 1.086 to 5.863, respectively). In the subgroup analysis, systolic IAND ≥15 mm Hg was independently associated with MACEs in older patients (age ≥65 years) (HR 2.242, 95% CI 1.170 to 4.298) but not in younger patients (age <65 years). Conclusions: Large IAND is independently associated with the long-term occurrence of MACEs in patients with CS without PAD. In particular, the association between IAND and MACEs is only valid in elderly patients.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherBMJ Publishing Group Ltd-
dc.relation.isPartOfBMJ OPEN-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleImpact of interankle blood pressure difference on major adverse cardiovascular events in cryptogenic stroke patients without peripheral artery disease: a retrospective cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorMinho Han-
dc.contributor.googleauthorMinyoul Baik-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorJunghye Choi-
dc.contributor.googleauthorKangsik Seo-
dc.contributor.googleauthorEunjeong Park-
dc.contributor.googleauthorJi Hoe Heo-
dc.contributor.googleauthorHyo Suk Nam-
dc.identifier.doi10.1136/bmjopen-2021-054760-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA05987-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ00380-
dc.identifier.eissn2044-6055-
dc.identifier.pmid35197347-
dc.subject.keywordneurology-
dc.subject.keywordstroke-
dc.subject.keywordvascular medicine-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.affiliatedAuthor김영대-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor백민렬-
dc.contributor.affiliatedAuthor허지회-
dc.citation.volume12-
dc.citation.number2-
dc.citation.startPagee054760-
dc.identifier.bibliographicCitationBMJ OPEN, Vol.12(2) : e054760, 2022-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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