Cited 22 times in
Metabolic Dysfunction-Associated Fatty Liver Disease Increases Colon Cancer Risk: A Nationwide Cohort Study
DC Field | Value | Language |
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dc.contributor.author | 김승업 | - |
dc.contributor.author | 김현창 | - |
dc.contributor.author | 이혜원 | - |
dc.contributor.author | 이호규 | - |
dc.date.accessioned | 2022-03-11T10:59:41Z | - |
dc.date.available | 2022-03-11T10:59:41Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188090 | - |
dc.description.abstract | Introduction: The association between nonalcoholic fatty liver disease (NAFLD) and colorectal cancer (CRC) has been controversial. Using the new consensus-driven definition, we evaluated the association of metabolic dysfunction-associated fatty liver disease (MAFLD) with the risk of developing CRC. Methods: From a nationwide health screening database, we included 8,933,017 participants (48.6% male) aged 40-64 years between 2009 and 2010. Participants were categorized by the presence of fatty liver disease (FLD)-NAFLD and MAFLD, separately-and by the combination of the 2 definitions: neither FLD, NAFLD only, MAFLD only, or both FLD. The primary outcome was the development of CRC. Results: Among the participants, 2,517,330 (28.2%) had NAFLD, and 3,337,122 (37.4%) had MAFLD, whereas 2,465,151 (27.6%) met both NAFLD and MAFLD definitions. Over a median follow-up period of 10.1 years, 60,888 new CRC cases developed. NAFLD and MAFLD were each associated with a significantly higher risk of developing CRC. When the neither FLD group was the reference, multivariable-adjusted hazard ratios (95% confidence interval) for CRC were 1.16 (1.06-1.28) in the NAFLD only group, 1.18 (1.16-1.20) in the both FLD group, and 1.32 (1.28-1.35) in the MAFLD only group. The presence of advanced liver fibrosis further increased CRC risk in each FLD group. Discussion: FLD was associated with a higher risk of CRC development. CRC risk was higher in the presence of MAFLD, especially when accompanied by liver fibrosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wolters Kluwer Health | - |
dc.relation.isPartOf | CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Colonic Neoplasms* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease* / complications | - |
dc.subject.MESH | Non-alcoholic Fatty Liver Disease* / epidemiology | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.title | Metabolic Dysfunction-Associated Fatty Liver Disease Increases Colon Cancer Risk: A Nationwide Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hokyou Lee | - |
dc.contributor.googleauthor | Hye Won Lee | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.identifier.doi | 10.14309/ctg.0000000000000435 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A01142 | - |
dc.contributor.localId | A03318 | - |
dc.contributor.localId | A05838 | - |
dc.relation.journalcode | J03632 | - |
dc.identifier.eissn | 2155-384X | - |
dc.identifier.pmid | 35080508 | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | 김승업 | - |
dc.contributor.affiliatedAuthor | 김현창 | - |
dc.contributor.affiliatedAuthor | 이혜원 | - |
dc.contributor.affiliatedAuthor | 이호규 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | e00435 | - |
dc.identifier.bibliographicCitation | CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, Vol.13(1) : e00435, 2022-01 | - |
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