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Clinical features and treatment outcomes of resected large cell neuroendocrine carcinoma of the lung

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dc.contributor.author윤홍인-
dc.contributor.author이준교-
dc.contributor.author이창걸-
dc.contributor.author조재호-
dc.contributor.author최서희-
dc.contributor.author김태형-
dc.date.accessioned2022-03-11T10:57:29Z-
dc.date.available2022-03-11T10:57:29Z-
dc.date.issued2021-12-
dc.identifier.issn2234-1900-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188071-
dc.description.abstractPurpose: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a high-grade lung neuroendocrine tumor with a poor prognosis, similar to small cell lung cancer (SCLC). However, it remains unclear whether to treat LCNEC as non-small-cell lung cancer (NSCLC) or as SCLC. We reviewed our experiences to suggest appropriate treatment strategy for resected pulmonary LCNEC. Materials and methods: Forty-four patients were treated for pathologically diagnosed pulmonary LCNEC during 2005‒2018. We considered curative surgery first in early-stage or some locally advanced tumors, unless medically inoperable. Adjuvant treatments were decided considering patient's clinical and pathological features. After excluding two stage I tumors with radiotherapy alone and three stage III tumors with upfront chemotherapy, we analyzed 39 patients with stage I‒III pulmonary LCNEC, who underwent curative resection first. Results: Adjuvant chemotherapy (NSCLC-based 91%, SCLC-based 9%) was performed in 62%, and adjuvant radiotherapy was done in three patients for pN2 or positive margin. None received prophylactic cranial irradiation (PCI). With a median follow-up of 30 months, the 2- and 5-year overall survival (OS) rates were 68% and 51%, and the 2- and 5-year recurrence-free survival (RFS) rates were 49% and 43%, respectively. Aged ≥67 years and SCLC-mixed pathology were significant poor prognostic factors for OS or RFS (p < 0.05). Among 17 recurrences, regional failures were most common (n = 6), and there were five brain metastases. Conclusions: Surgery and adjuvant treatment (without PCI) could achieve favorable outcomes in pulmonary LCNEC, which was more similar to NSCLC, although some factors worsened the prognosis. The importance of intensified adjuvant therapies with multidisciplinary approach remains high.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society for Therapeutic Radiology and Oncology-
dc.relation.isPartOfRADIATION ONCOLOGY JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinical features and treatment outcomes of resected large cell neuroendocrine carcinoma of the lung-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorJin Young Moon-
dc.contributor.googleauthorSeo Hee Choi-
dc.contributor.googleauthorTae Hyung Kim-
dc.contributor.googleauthorJoongyo Lee-
dc.contributor.googleauthorJi Hoon Pyo-
dc.contributor.googleauthorYong Tae Kim-
dc.contributor.googleauthorSeo Jin Lee-
dc.contributor.googleauthorHong In Yoon-
dc.contributor.googleauthorJaeho Cho-
dc.contributor.googleauthorChang Geol Lee-
dc.identifier.doi10.3857/roj.2021.00423-
dc.contributor.localIdA04777-
dc.contributor.localIdA05800-
dc.contributor.localIdA03240-
dc.contributor.localIdA03901-
dc.contributor.localIdA04867-
dc.relation.journalcodeJ02592-
dc.identifier.eissn2234-3164-
dc.identifier.pmid34986550-
dc.subject.keywordCranial irradiation-
dc.subject.keywordLung neoplasms-
dc.subject.keywordNeuroendocrine tumors-
dc.subject.keywordPrognosis-
dc.subject.keywordSmall cell lung carcinoma-
dc.contributor.alternativeNameYoon, Hong In-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor이준교-
dc.contributor.affiliatedAuthor이창걸-
dc.contributor.affiliatedAuthor조재호-
dc.contributor.affiliatedAuthor최서희-
dc.citation.volume39-
dc.citation.number4-
dc.citation.startPage288-
dc.citation.endPage296-
dc.identifier.bibliographicCitationRADIATION ONCOLOGY JOURNAL, Vol.39(4) : 288-296, 2021-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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