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Modified (-)-gallocatechin gallate-enriched green tea extract rescues age-related cognitive deficits by restoring hippocampal synaptic plasticity

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dc.contributor.author정승수-
dc.date.accessioned2022-03-11T06:22:16Z-
dc.date.available2022-03-11T06:22:16Z-
dc.date.issued2022-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188055-
dc.description.abstractAging leads to cognitive impairments characterized by reduced hippocampal functions that are associated with impairment of long-term potentiation of CA1 synapses. Here, we assessed the safety and efficacy of modified (-)-gallocatechin gallate (GCG)-enriched green tea extract (HTP-GTE) in ameliorating the cognitive dysfunctions in late middle-aged murine model. We developed a novel HTP-GTE that was enriched with GCG via epimerization that involved heating. We compared the effects of oral administrations of conventional green tea and HTP-GTE in young and aged male C57/BL6 mice, and examined the changes in the hippocampal functions related to aging process. The functional outcome was assessed by the electrophysiological experiments to measure the long-term potentiation (LTP). HTP-GTE improved the age-related cognitive impairments via restoring long-term synaptic plasticity. We also identified that GCG was the main active component responsible for the HTP-GTE effect. The main molecular pathway in ameliorating the age-related cognitive dysfunctions involved protein kinase A (PKA) which was shown to be modulated by HTP-GTE. Thus, HTP-GTE has a therapeutic potential as a dietary supplement which may aid to rescue the impaired cognitive functions at the early phase of aging process through the modulation of LTP threshold.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier B.V.-
dc.relation.isPartOfBiochemistry and Biophysics Reports-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleModified (-)-gallocatechin gallate-enriched green tea extract rescues age-related cognitive deficits by restoring hippocampal synaptic plasticity-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Physiology (생리학교실)-
dc.contributor.googleauthorJi-Woong Ahn-
dc.contributor.googleauthorSohyun Kim-
dc.contributor.googleauthorSukjin Ko-
dc.contributor.googleauthorYoung-Hwan Kim-
dc.contributor.googleauthorJi-Hyun Jeong-
dc.contributor.googleauthorSeungsoo Chung-
dc.identifier.doi10.1016/j.bbrep.2022.101201-
dc.contributor.localIdA03643-
dc.relation.journalcodeJ02974-
dc.identifier.eissn2405-5808-
dc.identifier.pmid35198737-
dc.subject.keywordAging-
dc.subject.keywordDIC, differential interference contrast-
dc.subject.keywordDMSO, dimethyl sulfoxide-
dc.subject.keywordEGCG, (−)-epigallocatechin-3-gallate-
dc.subject.keywordGCG, (−)-gallocatechin gallate-
dc.subject.keywordGTE, conventional green tea extract-
dc.subject.keywordHPLC-PDA, high performance liquid chromatography photometric diode array-
dc.subject.keywordHTP-GTE, GCG-enriched green tea extract-
dc.subject.keywordHippocampus-
dc.subject.keywordLTP, long-term potentiation-
dc.subject.keywordLong-term potentiation-
dc.subject.keywordMTT, methylthiazolyldiphenyl-tetrazolium bromide-
dc.subject.keywordMWM, Morris water maze-
dc.subject.keywordMemory-
dc.subject.keywordNMDARs, N-Methyl-d-aspartate receptors-
dc.subject.keywordPKA, protein kinase A-
dc.subject.keywordSC, Schaffer collateral-
dc.subject.keywordTTX, tetrodotoxin-
dc.subject.keywordaCSF, artificial cerebrospinal fluid-
dc.subject.keywordfEPSPs, field excitatory postsynaptic potentials-
dc.subject.keyword−)-Gallocatechin gallate-
dc.contributor.alternativeNameChung, Seung Soo-
dc.contributor.affiliatedAuthor정승수-
dc.citation.volume29-
dc.citation.startPage101201-
dc.identifier.bibliographicCitationBiochemistry and Biophysics Reports, Vol.29 : 101201, 2022-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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