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Clinical impact of pneumothorax in patients with Pneumocystis jirovecii pneumonia and respiratory failure in an HIV-negative cohort

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dc.contributor.author강영애-
dc.contributor.author곽세현-
dc.contributor.author김민철-
dc.contributor.author김성렬-
dc.contributor.author김송이-
dc.contributor.author김영삼-
dc.contributor.author김은영-
dc.contributor.author박무석-
dc.contributor.author박병훈-
dc.contributor.author용승현-
dc.contributor.author이상훈-
dc.contributor.author이수환-
dc.contributor.author이은혜-
dc.contributor.author임아영-
dc.contributor.author정경수-
dc.contributor.author정지예-
dc.contributor.author최지수-
dc.contributor.author설창환-
dc.date.accessioned2022-03-11T06:17:25Z-
dc.date.available2022-03-11T06:17:25Z-
dc.date.issued2022-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188022-
dc.description.abstractBackground: Pneumocystis jirovecii pneumonia (PCP) with acute respiratory failure can result in development of pneumothorax during treatment. This study aimed to identify the incidence and related factors of pneumothorax in patients with PCP and acute respiratory failure and to analyze their prognosis. Methods: We retrospectively reviewed the occurrence of pneumothorax, including clinical characteristics and results of other examinations, in 119 non-human immunodeficiency virus patients with PCP and respiratory failure requiring mechanical ventilator treatment in a medical intensive care unit (ICU) at a tertiary-care center between July 2016 and April 2019. Results: During follow up duration, twenty-two patients (18.5%) developed pneumothorax during ventilator treatment, with 45 (37.8%) eventually requiring a tracheostomy due to weaning failure. Cytomegalovirus co-infection (odds ratio 13.9; p = 0.013) was related with occurrence of pneumothorax in multivariate analysis. And development of pneumothorax was not associated with need for tracheostomy and mortality. Furthermore, analysis of survivor after 28 days in ICU, patients without pneumothorax were significantly more successful in weaning from mechanical ventilator than the patients with pneumothorax (44% vs. 13.3%, p = 0.037). PCP patients without pneumothorax showed successful home discharges compared to those who without pneumothorax (p = 0.010). Conclusions: The development of pneumothorax increased in PCP patient with cytomegalovirus co-infection, pneumothorax might have difficulty in and prolonged weaning from mechanical ventilators, which clinicians should be aware of when planning treatment for such patients.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC PULMONARY MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinical impact of pneumothorax in patients with Pneumocystis jirovecii pneumonia and respiratory failure in an HIV-negative cohort-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJi Soo Choi-
dc.contributor.googleauthorSe Hyun Kwak-
dc.contributor.googleauthorMin Chul Kim-
dc.contributor.googleauthorChang Hwan Seol-
dc.contributor.googleauthorSung Ryeol Kim-
dc.contributor.googleauthorByung Hoon Park-
dc.contributor.googleauthorEun Hye Lee-
dc.contributor.googleauthorSeung Hyun Yong-
dc.contributor.googleauthorAh Young Leem-
dc.contributor.googleauthorSong Yee Kim-
dc.contributor.googleauthorSang Hoon Lee-
dc.contributor.googleauthorKyungsoo Chung-
dc.contributor.googleauthorEun Young Kim-
dc.contributor.googleauthorJi Ye Jung-
dc.contributor.googleauthorYoung Ae Kang-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorSu Hwan Lee-
dc.identifier.doi10.1186/s12890-021-01812-z-
dc.contributor.localIdA00057-
dc.contributor.localIdA06039-
dc.contributor.localIdA06205-
dc.contributor.localIdA00566-
dc.contributor.localIdA00626-
dc.contributor.localIdA00707-
dc.contributor.localIdA00811-
dc.contributor.localIdA01457-
dc.contributor.localIdA01478-
dc.contributor.localIdA06000-
dc.contributor.localIdA02836-
dc.contributor.localIdA02904-
dc.contributor.localIdA03053-
dc.contributor.localIdA03382-
dc.contributor.localIdA03570-
dc.contributor.localIdA03735-
dc.contributor.localIdA05057-
dc.relation.journalcodeJ00375-
dc.identifier.eissn1471-2466-
dc.identifier.pmid34996422-
dc.subject.keywordPneumocystis-
dc.subject.keywordPneumonia-
dc.subject.keywordPneumothorax-
dc.subject.keywordPrognosis-
dc.subject.keywordRespiratory insufficiency-
dc.subject.keywordRisk factors-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.affiliatedAuthor강영애-
dc.contributor.affiliatedAuthor곽세현-
dc.contributor.affiliatedAuthor김민철-
dc.contributor.affiliatedAuthor김성렬-
dc.contributor.affiliatedAuthor김송이-
dc.contributor.affiliatedAuthor김영삼-
dc.contributor.affiliatedAuthor김은영-
dc.contributor.affiliatedAuthor박무석-
dc.contributor.affiliatedAuthor박병훈-
dc.contributor.affiliatedAuthor용승현-
dc.contributor.affiliatedAuthor이상훈-
dc.contributor.affiliatedAuthor이수환-
dc.contributor.affiliatedAuthor이은혜-
dc.contributor.affiliatedAuthor임아영-
dc.contributor.affiliatedAuthor정경수-
dc.contributor.affiliatedAuthor정지예-
dc.contributor.affiliatedAuthor최지수-
dc.citation.volume22-
dc.citation.number1-
dc.citation.startPage7-
dc.identifier.bibliographicCitationBMC PULMONARY MEDICINE, Vol.22(1) : 7, 2022-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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