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The Immunomodulating Effects of Thalidomide and Dexamethasone in a Murine Cardiac Allograft Transplantation Model
DC Field | Value | Language |
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dc.contributor.author | 김명수 | - |
dc.contributor.author | 김범석 | - |
dc.contributor.author | 김수진 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 허규하 | - |
dc.date.accessioned | 2022-03-11T06:16:36Z | - |
dc.date.available | 2022-03-11T06:16:36Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188017 | - |
dc.description.abstract | Purpose: The immunomodulatory effects of thalidomide (TM) and dexamethasone (DX) on immune cells and their co-stimulatory, co-inhibitory molecules in vitro and in vivo have been previously reported. The current study investigated the effects of TM and the combinatorial treatment with DX on immune cells using a murine cardiac allograft transplantation model. Materials and methods: Intraabdominal transplant of cardiac allografts from BALB/c (H-2d) donors to C57BL/6 (H-2b) recipients was performed. After transplantation, mice were injected daily with TM or DX or a combination of both TM and DX (TM/DX) by intraperitoneal route until the time of graft loss. CD4+ T cell subsets and CD11c+ cells in the peripheral blood mononuclear cells and spleen were examined and quantified with flow cytometry. Serum IL-6 levels were measured by enzyme-linked immunosorbent assay on day 7. Results: The mean graft survivals were 6.86 days in the untreated group, and 10.0 days in the TM/DX group (p<0.001). The TM/DX treatment affected the CD4+ T cell subsets without suppressing the total CD4+ T cell population. The CD4+FOXP3+/CD4+CD44hi T cell ratio increased. Increase in cell counts and median fluorescence intensity on CD11c+CD85k+ with TM/DX were observed. The inhibition of pro-inflammatory cytokine interleukin-6 was also observed. Conclusion: These outcomes suggest the immunomodulating effect of the TM/DX combinatorial treatment. In conclusion, TM/DX combination may be a promising immunomodulatory approach for preventing allograft rejection and improving graft survival by inducing tolerance in transplantation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Allografts | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dexamethasone | - |
dc.subject.MESH | Graft Rejection / drug therapy | - |
dc.subject.MESH | Graft Rejection / prevention & control | - |
dc.subject.MESH | Graft Survival | - |
dc.subject.MESH | Leukocytes, Mononuclear* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | T-Lymphocytes, Regulatory | - |
dc.subject.MESH | Thalidomide* / therapeutic use | - |
dc.title | The Immunomodulating Effects of Thalidomide and Dexamethasone in a Murine Cardiac Allograft Transplantation Model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Soo Jin Kim | - |
dc.contributor.googleauthor | Joon Ye Kim | - |
dc.contributor.googleauthor | Eun Jee Kim | - |
dc.contributor.googleauthor | Hyojung Lee | - |
dc.contributor.googleauthor | Yuri Cho | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.identifier.doi | 10.3349/ymj.2022.63.2.158 | - |
dc.contributor.localId | A00424 | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A00636 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A04344 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 35083901 | - |
dc.subject.keyword | Immunomodulation | - |
dc.subject.keyword | T cells | - |
dc.subject.keyword | cardiac transplantation | - |
dc.subject.keyword | dendritic cells | - |
dc.subject.keyword | dexamethasone | - |
dc.subject.keyword | thalidomide | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.affiliatedAuthor | 김명수 | - |
dc.contributor.affiliatedAuthor | 김범석 | - |
dc.contributor.affiliatedAuthor | 김수진 | - |
dc.contributor.affiliatedAuthor | 김유선 | - |
dc.contributor.affiliatedAuthor | 허규하 | - |
dc.citation.volume | 63 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 158 | - |
dc.citation.endPage | 165 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.63(2) : 158-165, 2022-02 | - |
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