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The Immunomodulating Effects of Thalidomide and Dexamethasone in a Murine Cardiac Allograft Transplantation Model

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dc.contributor.author김명수-
dc.contributor.author김범석-
dc.contributor.author김수진-
dc.contributor.author김유선-
dc.contributor.author허규하-
dc.date.accessioned2022-03-11T06:16:36Z-
dc.date.available2022-03-11T06:16:36Z-
dc.date.issued2022-02-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/188017-
dc.description.abstractPurpose: The immunomodulatory effects of thalidomide (TM) and dexamethasone (DX) on immune cells and their co-stimulatory, co-inhibitory molecules in vitro and in vivo have been previously reported. The current study investigated the effects of TM and the combinatorial treatment with DX on immune cells using a murine cardiac allograft transplantation model. Materials and methods: Intraabdominal transplant of cardiac allografts from BALB/c (H-2d) donors to C57BL/6 (H-2b) recipients was performed. After transplantation, mice were injected daily with TM or DX or a combination of both TM and DX (TM/DX) by intraperitoneal route until the time of graft loss. CD4+ T cell subsets and CD11c+ cells in the peripheral blood mononuclear cells and spleen were examined and quantified with flow cytometry. Serum IL-6 levels were measured by enzyme-linked immunosorbent assay on day 7. Results: The mean graft survivals were 6.86 days in the untreated group, and 10.0 days in the TM/DX group (p<0.001). The TM/DX treatment affected the CD4+ T cell subsets without suppressing the total CD4+ T cell population. The CD4+FOXP3+/CD4+CD44hi T cell ratio increased. Increase in cell counts and median fluorescence intensity on CD11c+CD85k+ with TM/DX were observed. The inhibition of pro-inflammatory cytokine interleukin-6 was also observed. Conclusion: These outcomes suggest the immunomodulating effect of the TM/DX combinatorial treatment. In conclusion, TM/DX combination may be a promising immunomodulatory approach for preventing allograft rejection and improving graft survival by inducing tolerance in transplantation.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAllografts-
dc.subject.MESHAnimals-
dc.subject.MESHDexamethasone-
dc.subject.MESHGraft Rejection / drug therapy-
dc.subject.MESHGraft Rejection / prevention & control-
dc.subject.MESHGraft Survival-
dc.subject.MESHLeukocytes, Mononuclear*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHT-Lymphocytes, Regulatory-
dc.subject.MESHThalidomide* / therapeutic use-
dc.titleThe Immunomodulating Effects of Thalidomide and Dexamethasone in a Murine Cardiac Allograft Transplantation Model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSoo Jin Kim-
dc.contributor.googleauthorJoon Ye Kim-
dc.contributor.googleauthorEun Jee Kim-
dc.contributor.googleauthorHyojung Lee-
dc.contributor.googleauthorYuri Cho-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorBeom Seok Kim-
dc.contributor.googleauthorKyu Ha Huh-
dc.identifier.doi10.3349/ymj.2022.63.2.158-
dc.contributor.localIdA00424-
dc.contributor.localIdA00488-
dc.contributor.localIdA00636-
dc.contributor.localIdA00785-
dc.contributor.localIdA04344-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid35083901-
dc.subject.keywordImmunomodulation-
dc.subject.keywordT cells-
dc.subject.keywordcardiac transplantation-
dc.subject.keyworddendritic cells-
dc.subject.keyworddexamethasone-
dc.subject.keywordthalidomide-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.affiliatedAuthor김명수-
dc.contributor.affiliatedAuthor김범석-
dc.contributor.affiliatedAuthor김수진-
dc.contributor.affiliatedAuthor김유선-
dc.contributor.affiliatedAuthor허규하-
dc.citation.volume63-
dc.citation.number2-
dc.citation.startPage158-
dc.citation.endPage165-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.63(2) : 158-165, 2022-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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