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Children's Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) System for Pediatric Patients with Hepatoblastoma: A Retrospective, Hospital-Based Cohort Study in South Korea

DC Field Value Language
dc.contributor.author신현주-
dc.contributor.author유철주-
dc.contributor.author윤혜성-
dc.contributor.author이미정-
dc.contributor.author한승민-
dc.contributor.author한정우-
dc.date.accessioned2022-03-11T06:06:54Z-
dc.date.available2022-03-11T06:06:54Z-
dc.date.issued2022-01-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187946-
dc.description.abstractPurpose: In 2017, the Children's Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system was introduced. We aimed to evaluate the accuracy of CHIC-HS System for the prediction of event-free survival (EFS) in Korean pediatric patients with hepatoblastoma. Materials and methods: This two-center retrospective study included consecutive Korean pediatric patients with histopathologically confirmed hepatoblastoma from March 1988 through September 2019. We compared EFS among four risk groups according to the CHIC-HS system. Discriminatory ability of CHIC-HS system was also evaluated using optimism-corrected C-statistics. Factors associated with EFS were explored using multivariable Cox regression analysis. Results: We included 129 patients (mean age, 2.6±3.3 years; female:male, 63:66). The 5-year EFS rates in the very low, low, intermediate, and high-risk groups, according to the CHIC-HS system were 90.0%, 82.8%, 73.5%, and 51.3%, respectively. The CHIC-HS system aligned significantly well with EFS outcomes (p=0.004). The optimism-corrected C index of CHIC-HS was 0.644 (95% confidence interval [CI], 0.561 to 0.727). Age ≥ 8 (vs. age ≤ 2; hazard ratio [HR], 2.781; 95% CI, 1.187 to 6.512; p=0.018), PRE-Treatment EXTent of tumor (PRETEXT) stage IV (vs. PRETEXT I or II; HR, 2.774; 95% CI, 1.228 to 5.974; p=0.009), and presence of metastasis (HR, 2.886; 95% CI, 1.457 to 5.719; p=0.002), which are incorporated as the first three nodes in the CHIC-HS system, were independently associated with EFS. Conclusion: The CHIC-HS system aligned significantly well with EFS outcomes in Korean pediatric patients with hepatoblastoma. Age group, PRETEXT stage, and presence of metastasis were independently associated with EFS.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleChildren's Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) System for Pediatric Patients with Hepatoblastoma: A Retrospective, Hospital-Based Cohort Study in South Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorPyeong Hwa Kim-
dc.contributor.googleauthorHyun Joo Shin-
dc.contributor.googleauthorHee Mang Yoon-
dc.contributor.googleauthorYoung Hun Choi-
dc.contributor.googleauthorJung-Man Namgoong-
dc.contributor.googleauthorDae Yeon Kim-
dc.contributor.googleauthorKyung-Nam Koh-
dc.contributor.googleauthorMi-Jung Lee-
dc.contributor.googleauthorHaesung Yoon-
dc.contributor.googleauthorChuhl Joo Lyu-
dc.contributor.googleauthorJung Woo Han-
dc.contributor.googleauthorSeung Min Hahn-
dc.contributor.googleauthorYoung Ah Cho-
dc.identifier.doi10.4143/crt.2021.265-
dc.contributor.localIdA02178-
dc.contributor.localIdA02524-
dc.contributor.localIdA04989-
dc.contributor.localIdA02774-
dc.contributor.localIdA04299-
dc.contributor.localIdA04325-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid33781052-
dc.subject.keywordCHIC-HS-
dc.subject.keywordChild-
dc.subject.keywordHepatoblastoma-
dc.subject.keywordPRETEXT-
dc.subject.keywordPediatrics-
dc.subject.keywordSurvival-
dc.contributor.alternativeNameShin, Hyun Joo-
dc.contributor.affiliatedAuthor신현주-
dc.contributor.affiliatedAuthor유철주-
dc.contributor.affiliatedAuthor윤혜성-
dc.contributor.affiliatedAuthor이미정-
dc.contributor.affiliatedAuthor한승민-
dc.contributor.affiliatedAuthor한정우-
dc.citation.volume54-
dc.citation.number1-
dc.citation.startPage253-
dc.citation.endPage258-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.54(1) : 253-258, 2022-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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