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Added value of abbreviated breast magnetic resonance imaging for assessing suspicious microcalcification on screening mammography-a prospective study

 Hye Mi Gweon  ;  Na Lae Eun  ;  Ji Hyun Youk  ;  Joon Jeong  ;  Soong June Bae  ;  Sung Gwe Ahn  ;  Jeong-Ah Kim  ;  Eun Ju Son 
 EUROPEAN RADIOLOGY, Vol.32(2) : 815-821, 2022-02 
Journal Title
Issue Date
Breast / diagnostic imaging ; Breast Neoplasms* / diagnostic imaging ; Calcinosis* / diagnostic imaging ; Early Detection of Cancer ; Female ; Humans ; Magnetic Resonance Imaging ; Mammography ; Prospective Studies ; Sensitivity and Specificity
Breast neoplasm ; Calcification ; Magnetic resonance imaging ; Screening
Objectives: To investigate the added diagnostic value of abbreviated breast magnetic resonance imaging (MRI) for suspicious microcalcifications on screening mammography.

Methods: This prospective study included 80 patients with suspicious calcifications on screening mammography who underwent abbreviated MRI before undergoing breast biopsy between August 2017 and September 2020. The abbreviated protocol included one pre-contrast and the first post-contrast T1-weighted series. MRI examinations were interpreted as either positive or negative based on the visibility of any significant enhancement. The positive predictive value (PPV) was compared before and after the MRI.

Results: Of the 80 suspicious microcalcifications, 33.8% (27/80) were malignant and 66.2% (53/80) were false positives. Abbreviated MRI revealed 33 positive enhancement lesions, and 25 and two lesions showed true-positive and false-negative findings, respectively. Abbreviated MRI increased PPV from 33.8 (27 of 80 cases; 95% CI: 26.2%, 40.8%) to 75.8% (25 of 33 cases; 95% CI: 62.1%, 85.7%). A total of 85% (45 of 53) false-positive diagnoses were reduced after abbreviated MRI assessment.

Conclusions: Abbreviated MRI added significant diagnostic value in patients with suspicious microcalcifications on screening mammography, as demonstrated by a significant increase in PPV with a potential reduction in unnecessary biopsy.

Key points: • Abbreviated breast magnetic resonance imaging increased the positive predictive value of suspicious microcalcifications on screening mammography from 33.8 (27/80 cases) to 75.8% (25/33 cases) (p < .01). • Abbreviated magnetic resonance imaging helped avoid unnecessary benign biopsies in 85% (45/53 cases) of lesions without missing invasive cancer.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Gweon, Hye Mi(권혜미) ORCID logo https://orcid.org/0000-0002-3054-1532
Kim, Jeong Ah(김정아) ORCID logo https://orcid.org/0000-0003-4949-4913
Bae, Soong June(배숭준) ORCID logo https://orcid.org/0000-0002-0012-9694
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
Eun, Na Lae(은나래) ORCID logo https://orcid.org/0000-0002-7299-3051
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
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