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Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years

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dc.contributor.author권혁문-
dc.contributor.author김인수-
dc.contributor.author김종윤-
dc.contributor.author민필기-
dc.contributor.author윤영원-
dc.contributor.author이병권-
dc.contributor.author임세중-
dc.contributor.author최의영-
dc.contributor.author홍범기-
dc.date.accessioned2022-03-11T05:51:14Z-
dc.date.available2022-03-11T05:51:14Z-
dc.date.issued2021-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187832-
dc.description.abstractBackground: Atrial fibrillation (AF) has a heterogeneous pathophysiology according to individual patient characteristics. This study aimed to identify the effects of widely known risk factors on AF incidence according to age and to elucidate the clinical implications of these effects. Methods and results: We analyzed data from 501,668 subjects (≥18years old) without AF and valvular heart disease from the Korean National Health Insurance Service-National Sample Cohort. The total population was divided into two groups according to age, <60years and ≥60years. AF occurred in 0.7% of the overall population (3,416 of 501,668) during the follow-up period (mean 47.6 months). In Cox regression analysis, age, male sex, previous ischemic stroke, heart failure, and hypertension were related to increased risk of new-onset AF in both age groups. Especially in the <60years age group, risk of new-onset AF was increased by relatively modifiable risk factors: obesity (body mass index ≥25kg/m2; hazard ratio[HR] 1.37 [1.22-1.55], p<0.001, interaction p<0.001), and hypertension (HR 1.93[1.69-2.22], p<0.001, interaction p<0.001). Although interactions were not significant, chronic obstructive pulmonary disease (HR 1.41[1.24-1.60], p<0.001) and chronic kidney disease (HR 1.28[1.15-1.41], p<0.001) showed increased trends of the risk of new-onset AF in the ≥60years age group. Conclusion: The risk profile for new-onset AF was somewhat different between the <60years and the ≥60years age groups. Compared to the ≥60years group, relatively modifiable risk factors (such as obesity and hypertension) had a greater impact on AF incidence in the <60years age group. Different management strategies to prevent AF development according to age may be needed.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAge of Onset-
dc.subject.MESHAged-
dc.subject.MESHAtrial Fibrillation / complications-
dc.subject.MESHAtrial Fibrillation / epidemiology*-
dc.subject.MESHAtrial Fibrillation / physiopathology-
dc.subject.MESHBody Mass Index-
dc.subject.MESHFemale-
dc.subject.MESHHeart Failure / complications-
dc.subject.MESHHeart Failure / epidemiology*-
dc.subject.MESHHeart Failure / physiopathology-
dc.subject.MESHHumans-
dc.subject.MESHHypertension / complications-
dc.subject.MESHHypertension / epidemiology-
dc.subject.MESHHypertension / physiopathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHObesity / complications-
dc.subject.MESHObesity / epidemiology-
dc.subject.MESHObesity / physiopathology-
dc.subject.MESHPulmonary Disease, Chronic Obstructive / complications-
dc.subject.MESHPulmonary Disease, Chronic Obstructive / epidemiology-
dc.subject.MESHPulmonary Disease, Chronic Obstructive / physiopathology-
dc.subject.MESHRenal Insufficiency, Chronic / complications-
dc.subject.MESHRenal Insufficiency, Chronic / epidemiology-
dc.subject.MESHRenal Insufficiency, Chronic / physiopathology-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHStroke / complications-
dc.subject.MESHStroke / epidemiology*-
dc.subject.MESHStroke / physiopathology-
dc.titleComparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorIn-Soo Kim-
dc.contributor.googleauthorYeon-Jik Choi-
dc.contributor.googleauthorEui-Young Choi-
dc.contributor.googleauthorPil-Ki Min-
dc.contributor.googleauthorYoung Won Yoon-
dc.contributor.googleauthorByoung Kwon Lee-
dc.contributor.googleauthorBum-Kee Hong-
dc.contributor.googleauthorSe-Joong Rim-
dc.contributor.googleauthorHyuck Moon Kwon-
dc.contributor.googleauthorJong-Youn Kim-
dc.identifier.doi10.1371/journal.pone.0258770-
dc.contributor.localIdA00260-
dc.contributor.localIdA00840-
dc.contributor.localIdA00926-
dc.contributor.localIdA01412-
dc.contributor.localIdA02580-
dc.contributor.localIdA02793-
dc.contributor.localIdA03372-
dc.contributor.localIdA04165-
dc.contributor.localIdA04394-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid34793457-
dc.contributor.alternativeNameKwon, Hyuck Moon-
dc.contributor.affiliatedAuthor권혁문-
dc.contributor.affiliatedAuthor김인수-
dc.contributor.affiliatedAuthor김종윤-
dc.contributor.affiliatedAuthor민필기-
dc.contributor.affiliatedAuthor윤영원-
dc.contributor.affiliatedAuthor이병권-
dc.contributor.affiliatedAuthor임세중-
dc.contributor.affiliatedAuthor최의영-
dc.contributor.affiliatedAuthor홍범기-
dc.citation.volume16-
dc.citation.number11-
dc.citation.startPagee0258770-
dc.identifier.bibliographicCitationPLOS ONE, Vol.16(11) : e0258770, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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