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Apparent treatment-resistant hypertension among ambulatory hypertensive patients: a cross-sectional study from 13 general hospitals

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dc.contributor.author강석민-
dc.date.accessioned2022-03-11T05:50:13Z-
dc.date.available2022-03-11T05:50:13Z-
dc.date.issued2021-07-
dc.identifier.issn1226-3303-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187823-
dc.description.abstractBackground/aims: To examine the prevalence and clinical characteristics of apparent treatment-resistant hypertension among ambulatory hypertensive patients. Methods: We enrolled adult ambulatory hypertensive patients at 13 well-qualified general hospitals in Korea from January to June 2012. Apparent resistant hypertension was defined as an elevated blood pressure > 140/90 mmHg with the use of three antihypertensive agents, including diuretics, or ≥ 4 antihypertensives, regardless of the blood pressure. Controlled hypertension was defined as a blood pressure within the target using three antihypertensives, including diuretics. Results: Among 16,915 hypertensive patients, 1,172 (6.9%) had controlled hypertension, and 1,514 (8.9%) had apparent treatment-resistant hypertension. Patients with apparent treatment-resistant hypertension had an earlier onset of hypertension (56.8 years vs. 58.8 years, p = 0.007) and higher body mass index (26.3 kg/m2 vs. 24.9 kg/m2, p < 0.001) than those with controlled hypertension. Drug compliance did not differ between groups. In the multivariable analysis, earlier onset of hypertension (odds ratio [OR], 0.98; 95% confidence interval [CI], 0.97 to 0.99; p < 0.001) and the presence of comorbidities (OR, 2.06; 95% CI, 1.27 to 3.35; p < 0.001), such as diabetes mellitus, ischemic heart disease, heart failure, and chronic kidney disease, were independent predictors. Among the patients with apparent treatment-resistant hypertension, only 5.2% were receiving ≥ 2 antihypertensives at maximally tolerated doses. Conclusion: Apparent treatment-resistant hypertension prevalence is 8.9% among ambulatory hypertensive patients in Korea. An earlier onset of hypertension and the presence of comorbidities are independent predictors. Optimization of medical treatment may reduce the rate of apparent treatment-resistant hypertension.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Association of Internal Medicine-
dc.relation.isPartOfKOREAN JOURNAL OF INTERNAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAntihypertensive Agents / pharmacology-
dc.subject.MESHAntihypertensive Agents / therapeutic use-
dc.subject.MESHBlood Pressure-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHDrug Resistance-
dc.subject.MESHHospitals, General*-
dc.subject.MESHHumans-
dc.subject.MESHHypertension* / diagnosis-
dc.subject.MESHHypertension* / drug therapy-
dc.subject.MESHHypertension* / epidemiology-
dc.subject.MESHPrevalence-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.titleApparent treatment-resistant hypertension among ambulatory hypertensive patients: a cross-sectional study from 13 general hospitals-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSehun Kim-
dc.contributor.googleauthorJin Joo Park-
dc.contributor.googleauthorMi-Seung Shin-
dc.contributor.googleauthorChoong Hwan Kwak-
dc.contributor.googleauthorBong-Ryeol Lee-
dc.contributor.googleauthorSung-Ji Park-
dc.contributor.googleauthorHae-Young Lee-
dc.contributor.googleauthorSang-Hyun Kim-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorByung-Su Yoo-
dc.contributor.googleauthorJoong-Wha Chung-
dc.contributor.googleauthorSi Wan Choi-
dc.contributor.googleauthorSang-Ho Jo-
dc.contributor.googleauthorJinho Shin-
dc.contributor.googleauthorDong-Ju Choi-
dc.identifier.doi10.3904/kjim.2019.361-
dc.contributor.localIdA00037-
dc.relation.journalcodeJ02883-
dc.identifier.eissn2005-6648-
dc.identifier.pmid34092048-
dc.subject.keywordApparent treatment resistant hypertension-
dc.subject.keywordCharacteristics-
dc.subject.keywordIndependent predictor-
dc.subject.keywordKorea-
dc.subject.keywordPrevalence-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.citation.volume36-
dc.citation.number4-
dc.citation.startPage888-
dc.citation.endPage897-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF INTERNAL MEDICINE, Vol.36(4) : 888-897, 2021-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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