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Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014-2019

Authors
 Ki Wook Yun  ;  Kyuyol Rhie  ;  Jin Han Kang  ;  Kyung-Hyo Kim  ;  Jong Gyun Ahn  ;  Yae-Jean Kim  ;  Byung Wook Eun  ;  Sung Hee Oh  ;  Hye-Kyung Cho  ;  Young Jin Hong  ;  Nam Hee Kim  ;  Yun-Kyung Kim  ;  Hyunju Lee  ;  Taekjin Lee  ;  Hwang Min Kim  ;  Eun Young Cho  ;  Chun Soo Kim  ;  Su Eun Park  ;  Chi Eun Oh  ;  Dae Sun Jo  ;  Eun Song Song  ;  Jina Lee  ;  Jae Hong Choi  ;  Joon Kee Lee  ;  Hoan Jong Lee  ;  Eun Hwa Choi 
Citation
 VACCINE, Vol.39(40) : 5787-5793, 2021-09 
Journal Title
VACCINE
ISSN
 0264-410X 
Issue Date
2021-09
MeSH
Child ; Humans ; Pneumococcal Infections* / epidemiology ; Pneumococcal Vaccines* ; Republic of Korea / epidemiology ; Serogroup ; Streptococcus pneumoniae / genetics
Keywords
Children ; Genotype ; Serotype ; Streptococcus pneumoniae
Abstract
Replacement with nonvaccine serotypes (NVTs) among invasive pneumococcal diseases (IPDs) after the introduction of extended-valency pneumococcal conjugate vaccines varies in predominant serotypes across countries. This study analyzed changes in serotype distribution through serotyping, multilocus sequence typing, and antimicrobial susceptibility testing of 168 pediatric IPD isolates obtained from a multihospital-based surveillance system during 2014-2019 in South Korea. Vaccine serotypes (VTs) accounted for 16.1% (19A, 10.1%; 6A, 1.8%; and 19F 1.8%), 82.1% were NVTs (10A, 23.8%; 15A, 8.3%; 12F, 6.5%; 15C, 6.5%; and 15B, 6.0%), and three (1.8%) were nontypeable. Serotype 10A was the most common serotype, with a significant increase from 11.5% in 2014 to 33.3% in 2019 (p < 0.05 for the trend). Other NVTs decreased from 70.4% to 41.7% between 2015 and 2019, most notably in serotype 12F (from 14.8% to 0%). Almost all (95.0%) serotype 10A isolates were ST11189, which were multidrug resistant.
Full Text
https://www.sciencedirect.com/science/article/pii/S0264410X21011208
DOI
10.1016/j.vaccine.2021.08.072
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Jong Gyun(안종균) ORCID logo https://orcid.org/0000-0001-5748-0015
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187808
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