21 56

Cited 0 times in

Impact of insulin therapy on the mortality of acute heart failure patients with diabetes mellitus

DC Field Value Language
dc.contributor.author강석민-
dc.date.accessioned2022-03-11T05:48:52Z-
dc.date.available2022-03-11T05:48:52Z-
dc.date.issued2021-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187807-
dc.description.abstractBackground: Patients with diabetes mellitus (DM) have a higher prevalence of heart failure (HF) than those without it. Approximately 40 % of HF patients have DM and they tend to have poorer outcomes than those without DM. This study evaluated the impact of insulin therapy on mortality among acute HF patients. Methods: A total of 1740 patients from the Korean Acute Heart Failure registry with DM were included in this study. The risk of all-cause mortality according to insulin therapy was assessed using the Cox proportional hazard models with inverse probability of treatment weighting to balance the clinical characteristics (pretreatment covariates) between the groups. Results: DM patients had been treated with either oral hypoglycemic agents (OHAs) alone (n = 620), insulin alone (n = 682), or insulin combined with OHAs (n = 438). The insulin alone group was associated with an increased mortality risk compared with the OHA alone group (HR = 1.41, 95 % CI 1.21-1.66]). Insulin therapy combined with OHAs also showed an increased mortality risk (HR = 1.29, 95 % CI 1.14-1.46) compared with the OHA alone group. Insulin therapy was consistently associated with increased mortality risk, regardless of the left ventricular ejection fraction (LVEF) or HF etiology. A significant increase in mortality was observed in patients with good glycemic control (HbA1c < 7.0 %) receiving insulin, whereas there was no significant association in patients with poor glycemic control (HbA1c ≥ 7.0%). Conclusions: Insulin therapy was found to be associated with increased mortality compared to OHAs. The insulin therapy was harmful especially in patients with low HbA1c levels which may suggest the necessity of specific management strategies and blood sugar targets when using insulin in patients with HF.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfCARDIOVASCULAR DIABETOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAcute Disease-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers / blood-
dc.subject.MESHBlood Glucose / drug effects-
dc.subject.MESHBlood Glucose / metabolism-
dc.subject.MESHDiabetes Mellitus / blood-
dc.subject.MESHDiabetes Mellitus / diagnosis-
dc.subject.MESHDiabetes Mellitus / drug therapy*-
dc.subject.MESHDiabetes Mellitus / mortality-
dc.subject.MESHFemale-
dc.subject.MESHGlycated Hemoglobin A / metabolism-
dc.subject.MESHGlycemic Control* / adverse effects-
dc.subject.MESHGlycemic Control* / mortality-
dc.subject.MESHHeart Failure / diagnosis-
dc.subject.MESHHeart Failure / mortality*-
dc.subject.MESHHeart Failure / physiopathology-
dc.subject.MESHHumans-
dc.subject.MESHHypoglycemic Agents / adverse effects-
dc.subject.MESHHypoglycemic Agents / therapeutic use*-
dc.subject.MESHInsulin / adverse effects-
dc.subject.MESHInsulin / therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHRegistries-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleImpact of insulin therapy on the mortality of acute heart failure patients with diabetes mellitus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSe Yong Jang-
dc.contributor.googleauthorJieun Jang-
dc.contributor.googleauthorDong Heon Yang-
dc.contributor.googleauthorHyun-Jai Cho-
dc.contributor.googleauthorSoo Lim-
dc.contributor.googleauthorEun-Seok Jeon-
dc.contributor.googleauthorSang Eun Lee-
dc.contributor.googleauthorJae-Joong Kim-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorSang Hong Baek-
dc.contributor.googleauthorMyeong-Chan Cho-
dc.contributor.googleauthorDong-Ju Choi-
dc.contributor.googleauthorByung-Su Yoo-
dc.contributor.googleauthorKye Hun Kim-
dc.contributor.googleauthorSue K Park-
dc.contributor.googleauthorHae-Young Lee-
dc.identifier.doi10.1186/s12933-021-01370-y-
dc.contributor.localIdA00037-
dc.relation.journalcodeJ00460-
dc.identifier.eissn1475-2840-
dc.identifier.pmid34496864-
dc.subject.keywordDiabetes mellitus-
dc.subject.keywordHeart failure-
dc.subject.keywordInsulin-
dc.subject.keywordMortality-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.citation.volume20-
dc.citation.number1-
dc.citation.startPage180-
dc.identifier.bibliographicCitationCARDIOVASCULAR DIABETOLOGY, Vol.20(1) : 180, 2021-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.