Cited 8 times in
Statin Use and COVID-19 Infectivity and Severity in South Korea: Two Population-Based Nationwide Cohort Studies
DC Field | Value | Language |
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dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2022-02-23T01:29:13Z | - |
dc.date.available | 2022-02-23T01:29:13Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187727 | - |
dc.description.abstract | Background: Basic studies suggest that statins as add-on therapy may benefit patients with COVID-19; however, real-world evidence of such a beneficial association is lacking. Objective: We investigated differences in SARS-CoV-2 test positivity and clinical outcomes of COVID-19 (composite endpoint: admission to intensive care unit, invasive ventilation, or death) between statin users and nonusers. Methods: Two independent population-based cohorts were analyzed, and we investigated the differences in SARS-CoV-2 test positivity and severe clinical outcomes of COVID-19, such as admission to the intensive care unit, invasive ventilation, or death, between statin users and nonusers. One group comprised an unmatched cohort of 214,207 patients who underwent SARS-CoV-2 testing from the Global Research Collaboration Project (GRCP)-COVID cohort, and the other group comprised an unmatched cohort of 74,866 patients who underwent SARS-CoV-2 testing from the National Health Insurance Service (NHIS)-COVID cohort. Results: The GRCP-COVID cohort with propensity score matching had 29,701 statin users and 29,701 matched nonusers. The SARS-CoV-2 test positivity rate was not associated with statin use (statin users, 2.82% [837/29,701]; nonusers, 2.65% [787/29,701]; adjusted relative risk [aRR] 0.97; 95% CI 0.88-1.07). Among patients with confirmed COVID-19 in the GRCP-COVID cohort, 804 were statin users and 1573 were matched nonusers. Statin users were associated with a decreased likelihood of severe clinical outcomes (statin users, 3.98% [32/804]; nonusers, 5.40% [85/1573]; aRR 0.62; 95% CI 0.41-0.91) and length of hospital stay (statin users, 23.8 days; nonusers, 26.3 days; adjusted mean difference -2.87; 95% CI -5.68 to -0.93) than nonusers. The results of the NHIS-COVID cohort were similar to the primary results of the GRCP-COVID cohort. Conclusions: Our findings indicate that prior statin use is related to a decreased risk of worsening clinical outcomes of COVID-19 and length of hospital stay but not to that of SARS-CoV-2 infection. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | JMIR Publications | - |
dc.relation.isPartOf | JMIR PUBLIC HEALTH AND SURVEILLANCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | COVID-19 | - |
dc.subject.MESH | length of hospital stay | - |
dc.subject.MESH | severe clinical outcomes | - |
dc.subject.MESH | statin | - |
dc.subject.MESH | susceptibility | - |
dc.title | Statin Use and COVID-19 Infectivity and Severity in South Korea: Two Population-Based Nationwide Cohort Studies | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Seung Won Lee | - |
dc.contributor.googleauthor | So Young Kim | - |
dc.contributor.googleauthor | Sung Yong Moon | - |
dc.contributor.googleauthor | In Kyung Yoo | - |
dc.contributor.googleauthor | Eun-Gyong Yoo | - |
dc.contributor.googleauthor | Gwang Hyeon Eom | - |
dc.contributor.googleauthor | Jae-Min Kim | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Myung Ho Jeong | - |
dc.contributor.googleauthor | Jee Myung Yang | - |
dc.contributor.googleauthor | Dong Keon Yon | - |
dc.identifier.doi | 10.2196/29379 | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J04162 | - |
dc.identifier.pmid | 34623311 | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | e29379 | - |
dc.identifier.bibliographicCitation | JMIR PUBLIC HEALTH AND SURVEILLANCE, Vol.7(10) : e29379, 2021-10 | - |
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