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A partially hydrolyzed whey formula provides adequate nutrition in high-risk infants for allergy

Authors
 Jiyeon Yang  ;  Song I Yang  ;  Kyunguk Jeong  ;  Kyung Won Kim  ;  Yoon Hee Kim  ;  Taek Ki Min  ;  Bok Yang Pyun  ;  Jeongmin Lee  ;  Ji A Jung  ;  Jeong Hee Kim  ;  Sooyoung Lee 
Citation
 NUTRITION RESEARCH AND PRACTICE, Vol.16(3) : 344-353, 2022-06 
Journal Title
NUTRITION RESEARCH AND PRACTICE
ISSN
 1976-1457 
Issue Date
2022-06
Keywords
Infant formula ; nutritional sciences ; protein hydrolysates ; infant ; clinical trial
Abstract
BACKGROUND/OBJECTIVES
Hydrolyzed formula is often fed to infants with gastrointestinal or immune issues, such as malabsorption or cow's milk allergy, because enzymatic treatment has rendered it more digestible and less allergenic than standard cow's milk formula (SF). Partially hydrolyzed formula (PHF) should be considered for those infants who are intolerant to extensively hydrolyzed formula. However, there are concerns about the nutritional insufficiencies of PHF. We aimed to evaluate the effects of PHF on the growth and health indicators in infants who were at high-risk of allergic disease and potential candidates for consuming PHF.

SUBJECTS/METHODS
A total of 83 infants aged 0–2 mon with a family history of allergies were assigned to consume either PHF or SF until 24 weeks of age. Anthropometric measures were obtained at baseline, 12 weeks, and 24 weeks; blood samples were drawn and evaluated at the end of the study.

RESULTS
No significant differences were observed in weight, height, and weight-for-height at any time point in each sex between the PHF and SF groups. At 24 weeks of age, the weight-for-age and height-for-age z-scores of the SF group were higher than those of the PHF group, but there was no significant difference in the weight-for-height z-score. There were no significant differences in levels of white blood cells, hemoglobin, ferritin, protein, albumin, aspartate aminotransferase, alanine aminotransferase, eosinophil cationic protein, and immunoglobulin E.

CONCLUSIONS
In this study, there were no differences in growth and blood panels between the infants consuming PHF or SF. Therefore, infants who are unable to tolerate SF can be fed PHF without nutritional concerns about growth.
Files in This Item:
T202125095.pdf Download
DOI
10.4162/nrp.2022.16.3.344
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Yoon Hee(김윤희) ORCID logo https://orcid.org/0000-0002-2149-8501
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187689
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