Cited 3 times in
Pulmonary function of healthy Korean children from three independent birth cohorts: Validation of the Global Lung Function Initiative 2012 equation
DC Field | Value | Language |
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dc.contributor.author | 김경원 | - |
dc.date.accessioned | 2022-02-23T01:23:37Z | - |
dc.date.available | 2022-02-23T01:23:37Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 8755-6863 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187674 | - |
dc.description.abstract | Background and objective: Global Lung Function Initiative (GLI) 2012 equations were developed to resolve the age-related disparity in interpreting spirometry results. Local validation of the equation is needed, especially in Northeast Asian children. This study evaluated the GLI equation in Korean children. Methods: Spirometry indices (FEV1, FVC, FEV1/FVC, and FEF25%-75%) and clinical information were gathered from three population-based birth cohorts. Predicted GLI reference values and z scores of spirometry results were calculated for 1239 healthy children. The mean, standard deviation of z scores were compared with the expected 0 and 1. Probabilities of falling below the lower limit of normal (LLN) (z score: -1.64) were compared with the expected value 5%. GLI z scores were assessed according to low (<-2), normal (≥-2 and ≤2), and high (>2) BMI z score groups. Results: Mean z scores significantly differed from 0 for FEV1/FVC in males (mean [95% confidence interval]: 0.18 [0.08, 0.27]) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in females (-0.23 [-0.31, -0.15] and -0.26 [-0.36, -0.16], respectively). The standard deviation was larger than 1 for all variables in males and FVC and FEV1/FVC in females. The probability of falling below the LLN was significantly larger than 5% for FEV1 (12.13% [9.64, 14.77]), FVC (15.86% [13.06, 18.81]), and forced expiratory flow at 25%-75% of forced vital capacity (FEF25%-75%) (7.31% [5.29, 9.49]) in males and FVC (11.91% [9.40, 14.60]) in females. FEV1 and FVC z scores increased across low to high body mass index (BMI) groups, and FEV1/FVC decreased from low to high BMI groups. Conclusion: GLI equations marginally differ from real-world values, which should be considered by pulmonologists in practice or research. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | PEDIATRIC PULMONOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Birth Cohort* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Forced Expiratory Volume | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Reference Values | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Spirometry | - |
dc.subject.MESH | Vital Capacity | - |
dc.title | Pulmonary function of healthy Korean children from three independent birth cohorts: Validation of the Global Lung Function Initiative 2012 equation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Ji Soo Park | - |
dc.contributor.googleauthor | Dong In Suh | - |
dc.contributor.googleauthor | Yun Jung Choi | - |
dc.contributor.googleauthor | Kangmo Ahn | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.contributor.googleauthor | Youn Ho Shin | - |
dc.contributor.googleauthor | So-Yeon Lee | - |
dc.contributor.googleauthor | Hyun-Ju Cho | - |
dc.contributor.googleauthor | Eun Lee | - |
dc.contributor.googleauthor | Gwang Cheon Jang | - |
dc.contributor.googleauthor | Ji-Won Kwon | - |
dc.contributor.googleauthor | Yong Han Sun | - |
dc.contributor.googleauthor | Sung-Il Woo | - |
dc.contributor.googleauthor | You-Sook Youn | - |
dc.contributor.googleauthor | Kang Seo Park | - |
dc.contributor.googleauthor | Myung-Hee Kook | - |
dc.contributor.googleauthor | Hwa Jin Cho | - |
dc.contributor.googleauthor | Hai Lee Chung | - |
dc.contributor.googleauthor | Ja Hyung Kim | - |
dc.contributor.googleauthor | Hyung Young Kim | - |
dc.contributor.googleauthor | Jin A Jung | - |
dc.contributor.googleauthor | Hyang-Ok Woo | - |
dc.contributor.googleauthor | Yoon Kyung Choi | - |
dc.contributor.googleauthor | Jeong Rim Lee | - |
dc.contributor.googleauthor | Young Ah Lee | - |
dc.contributor.googleauthor | Choong Ho Shin | - |
dc.contributor.googleauthor | Boong Nyun Kim | - |
dc.contributor.googleauthor | Johanna I Kim | - |
dc.contributor.googleauthor | Kyung-Shin Lee | - |
dc.contributor.googleauthor | Youn Hee Lim | - |
dc.contributor.googleauthor | Yun-Chul Hong | - |
dc.contributor.googleauthor | Soo-Jong Hong | - |
dc.identifier.doi | 10.1002/ppul.25622 | - |
dc.contributor.localId | A00303 | - |
dc.relation.journalcode | J02491 | - |
dc.identifier.eissn | 1099-0496 | - |
dc.identifier.pmid | 34375041 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/ppul.25622 | - |
dc.subject.keyword | Asian | - |
dc.subject.keyword | Global Lung Function Initiative | - |
dc.subject.keyword | children | - |
dc.subject.keyword | reference equation | - |
dc.subject.keyword | spirometry | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | 김경원 | - |
dc.citation.volume | 56 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 3310 | - |
dc.citation.endPage | 3320 | - |
dc.identifier.bibliographicCitation | PEDIATRIC PULMONOLOGY, Vol.56(10) : 3310-3320, 2021-10 | - |
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