66 92

Cited 0 times in

Factors Associated with Energy Efficiency of Focused Ultrasound Through the Skull: A Study of 3D-Printed Skull Phantoms and Its Comparison with Clinical Experiences

Authors
 Chanho Kong  ;  So Hee Park  ;  Jaewoo Shin  ;  Hee Gyu Baek  ;  Juyoung Park  ;  Young Cheol Na  ;  Won Seok Chang  ;  Jin Woo Chang 
Citation
 FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, Vol.9 : 783048, 2021-12 
Journal Title
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
Issue Date
2021-12
Keywords
3D print ; blood-brain barrier ; energy transmission ; focused ultrasound ; skull density ratio ; skull factor
Abstract
While focused ultrasound (FUS) is non-invasive, the ultrasound energy is attenuated by the skull which results in differences in energy efficiency among patients. In this study, we investigated the effect of skull variables on the energy efficiency of FUS. The thickness and density of the skull and proportion of the trabecular bone were selected as factors that could affect ultrasound energy transmittance. Sixteen 3D-printed skull models were designed and fabricated to reflect the three factors. The energy of each phantom was measured using an ultrasonic sound field energy measurement system. The thickness and proportion of trabecular bone affected the attenuation of transmitted energy. There was no difference in the density of the trabecular bone. In clinical data, the trabecular bone ratio showed a significantly greater correlation with dose/delivered energy than that of thickness and the skull density ratio. Currently, for clinical non-thermal FUS, the data are not sufficient, but we believe that the results of this study will be helpful in selecting patients and appropriate parameters for FUS treatment.
Files in This Item:
T202124992.pdf Download
DOI
10.3389/fbioe.2021.783048
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Park, So Hee(박소희)
Shin, Jaewoo(신재우) ORCID logo https://orcid.org/0000-0002-6335-1292
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187633
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links