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Novel prognostic classification predicts overall survival of patients receiving salvage whole-brain radiotherapy for recurrent brain metastasis from breast cancer: A recursive partitioning analysis (KROG 16-12)
DC Field | Value | Language |
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dc.contributor.author | 김용배 | - |
dc.contributor.author | 장지석 | - |
dc.date.accessioned | 2022-02-23T01:18:40Z | - |
dc.date.available | 2022-02-23T01:18:40Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0960-9776 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187627 | - |
dc.description.abstract | Background: To investigate outcomes of salvage whole-brain radiotherapy (WBRT) for recurrent brain metastases (BM) from breast cancer (BC), to identify prognostic factors of overall survival (OS), and to propose a novel prognostic classification for OS in these patients. Materials and methods: We identified 54 patients who had received salvage WBRT as the second brain-focused treatment for recurrent BM from BC (2000-2014). The median follow-up duration was 4.9 months. A recursive partitioning analysis (RPA) was conducted to develop a model to predict OS at the time of salvage WBRT. Results: The median OS was 6.8 months. OS according to BC-specific graded prognostic assessment (breast-GPA), modified breast-GPA, and updated breast-GPA did not represent our cohort. In the multivariate analysis, a long time before salvage WBRT (≥16 months), control of primary BC or extracranial metastases, systemic treatment after salvage WBRT, and administration of a biologically effective dose for an α/β of 10 Gy (BED10) of salvage WBRT >37.5 Gy showed superior OS. We proposed three RPA classes based on the control of both primary BC and extracranial metastasis and BED10 of salvage WBRT: class I, class II, and class III. In this model, patients with class I experienced the best OS (34.6 months; class II, 5.0 months; class III, 2.4 months; P < 0.001). Conclusions: In our RPA classification according to the control of both primary BC and extracranial metastasis and the dose of salvage WBRT, significant differences in OS were observed. The subsequent use of a systemic treatment showed better OS. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BREAST | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Brain | - |
dc.subject.MESH | Brain Neoplasms* / radiotherapy | - |
dc.subject.MESH | Brain Neoplasms* / surgery | - |
dc.subject.MESH | Breast Neoplasms* / radiotherapy | - |
dc.subject.MESH | Cranial Irradiation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neoplasm Recurrence, Local / radiotherapy | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Radiosurgery* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Novel prognostic classification predicts overall survival of patients receiving salvage whole-brain radiotherapy for recurrent brain metastasis from breast cancer: A recursive partitioning analysis (KROG 16-12) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Jae Sik Kim | - |
dc.contributor.googleauthor | Kyubo Kim | - |
dc.contributor.googleauthor | Wonguen Jung | - |
dc.contributor.googleauthor | Kyung Hwan Shin | - |
dc.contributor.googleauthor | Seock-Ah Im | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Doo Ho Choi | - |
dc.contributor.googleauthor | Haeyoung Kim | - |
dc.contributor.googleauthor | Yeon Hee Park | - |
dc.contributor.googleauthor | Dae Yong Kim | - |
dc.contributor.googleauthor | Tae Hyun Kim | - |
dc.contributor.googleauthor | Jeanny Kwon | - |
dc.contributor.googleauthor | Ki Mun Kang | - |
dc.contributor.googleauthor | Woong-Ki Chung | - |
dc.contributor.googleauthor | Kyung Su Kim | - |
dc.contributor.googleauthor | In Ah Kim | - |
dc.identifier.doi | 10.1016/j.breast.2021.11.005 | - |
dc.contributor.localId | A00744 | - |
dc.contributor.localId | A04658 | - |
dc.relation.journalcode | J00400 | - |
dc.identifier.eissn | 1532-3080 | - |
dc.identifier.pmid | 34814043 | - |
dc.subject.keyword | Brain metastasis | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Overall survival | - |
dc.subject.keyword | Recursive partitioning analysis | - |
dc.subject.keyword | Whole-brain radiotherapy | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | 김용배 | - |
dc.contributor.affiliatedAuthor | 장지석 | - |
dc.citation.volume | 60 | - |
dc.citation.startPage | 272 | - |
dc.citation.endPage | 278 | - |
dc.identifier.bibliographicCitation | BREAST, Vol.60 : 272-278, 2021-12 | - |
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