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Prognostic significance of T-cell-inflamed gene expression profile and PD-L1 expression in patients with esophageal cancer

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dc.contributor.author김현기-
dc.contributor.author김효송-
dc.contributor.author라선영-
dc.contributor.author정현철-
dc.date.accessioned2022-02-23T01:15:22Z-
dc.date.available2022-02-23T01:15:22Z-
dc.date.issued2021-12-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187603-
dc.description.abstractPurpose: The ability of the T-cell-inflamed gene expression profile (GEP) to predict clinical outcome in esophageal cancer (EC) is unknown. This retrospective observational study assessed the prognostic value of GEP and programmed death ligand 1 (PD-L1) expression in patients with EC treated in routine clinical practice. Methods: Tumor samples of 294 patients from three centers in Denmark, South Korea, and the United States, collected between 2005 and 2017, were included. T-cell-inflamed GEP score was defined as non-low or low using a cutoff of -1.54. A combined positive score (CPS) ≥10 was defined as PD-L1 expression positivity. Associations between overall survival (OS) and GEP status and PD-L1 expression were explored by Cox proportional hazards models adjusting for age, sex, histology, stage, and performance status. Results: Median age was 65 years; 63% of patients had adenocarcinoma (AC) and 37% had squamous cell carcinoma (SCC). Thirty-six percent of tumors were GEP non-low, with higher prevalence in AC (46%) than SCC (18%). Twenty-one percent were PD-L1-positive: 32% in South Korean samples versus 16% in non-Asian samples and 26% in SCC versus 18% in AC. GEP scores and PD-L1 CPS were weakly correlated (Spearman's R = 0.363). OS was not significantly associated with GEP status (non-low vs low; adjusted hazard ratio, 0.91 [95% CI, 0.69-1.19]) or PD-L1 expression status. Conclusion: Neither GEP nor PD-L1 expression was a prognostic marker in Asian and non-Asian patients with EC.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherJohn Wiley & Sons Ltd.-
dc.relation.isPartOfCANCER MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePrognostic significance of T-cell-inflamed gene expression profile and PD-L1 expression in patients with esophageal cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorTorben Steiniche-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorJeanette Baehr Georgsen-
dc.contributor.googleauthorMorten Ladekarl-
dc.contributor.googleauthorMarianne Nordsmark-
dc.contributor.googleauthorMarie Louise Jespersen-
dc.contributor.googleauthorHyo Song Kim-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorCarly Fein-
dc.contributor.googleauthorLaura H Tang-
dc.contributor.googleauthorTing Wu-
dc.contributor.googleauthorMatthew J Marton-
dc.contributor.googleauthorSenaka Peter-
dc.contributor.googleauthorDavid P Kelsen-
dc.contributor.googleauthorGeoffrey Ku-
dc.identifier.doi10.1002/cam4.4333-
dc.contributor.localIdA01108-
dc.contributor.localIdA01202-
dc.contributor.localIdA01316-
dc.contributor.localIdA03773-
dc.relation.journalcodeJ00449-
dc.identifier.eissn2045-7634-
dc.identifier.pmid34693652-
dc.subject.keywordT-lymphocytes-
dc.subject.keywordadenocarcinoma-
dc.subject.keywordretrospective study-
dc.subject.keywordsquamous cell carcinoma-
dc.contributor.alternativeNameKim, Hyunki-
dc.contributor.affiliatedAuthor김현기-
dc.contributor.affiliatedAuthor김효송-
dc.contributor.affiliatedAuthor라선영-
dc.contributor.affiliatedAuthor정현철-
dc.citation.volume10-
dc.citation.number23-
dc.citation.startPage8365-
dc.citation.endPage8376-
dc.identifier.bibliographicCitationCANCER MEDICINE, Vol.10(23) : 8365-8376, 2021-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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