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The Impact of Neoadjuvant Treatment on Survival in Patients Undergoing Pancreatoduodenectomy With Concomitant Portomesenteric Venous Resection: An International Multicenter Analysis

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dc.contributor.author윤동섭-
dc.contributor.author황호경-
dc.contributor.author박준성-
dc.date.accessioned2022-02-23T01:11:57Z-
dc.date.available2022-02-23T01:11:57Z-
dc.date.issued2021-11-
dc.identifier.issn0003-4932-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187581-
dc.description.abstractObjective: The aim of this study was to evaluate whether neoadjuvant therapy (NAT) critically influenced microscopically complete resection (R0) rates and long-term outcomes for patients with pancreatic ductal adenocarcinoma who underwent pancreatoduodenectomy (PD) with portomesenteric vein resection (PVR) from a diverse, world-wide group of high-volume centers. Summary of background data: Limited size studies suggest that NAT improves R0 rates and overall survival compared to upfront surgery in R/BR-PDAC patients. Methods: This multicenter study analyzed consecutive patients with R/BR-PDAC who underwent PD with PVR in 23 high-volume centers from 2009 to 2018. Results: Data from 1192 patients with PD and PVR were collected and analyzed. The median age was 68 [interquartile range (IQR) 60-73] years and 52% were males. Some 186 (15.6%) and 131 (10.9%) patients received neoadjuvant chemotherapy (NAC) alone and neoadjuvant chemoradiotherapy, respectively. The R0/R1/R2 rates were 57%, 39.3%, and 3.2% in patients who received NAT compared to 46.6%, 49.9%, and 3.5% in patients who did not, respectively (P =0.004). The 1-, 3-, and 5-year OS in patients receiving NAT was 79%, 41%, and 29%, while for those that did not it was 73%, 29%, and 18%, respectively (P <0.001). Multivariable analysis showed no administration of NAT, high tumor grade, lymphovascular invasion, R1/R2 resection, no adjuvant chemotherapy, occurrence of Clavien-Dindo grade 3 or higher postoperative complications within 90 days, preoperative diabetes mellitus, male sex and portal vein involvement were negative independent predictive factors for OS. Conclusion: Patients with PDAC of the pancreatic head expected to undergo venous reconstruction should routinely be considered for NAT.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfANNALS OF SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHEurope / epidemiology-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMesenteric Veins / surgery*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoadjuvant Therapy-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPancreas / blood supply*-
dc.subject.MESHPancreas / surgery-
dc.subject.MESHPancreatic Neoplasms / blood supply-
dc.subject.MESHPancreatic Neoplasms / mortality-
dc.subject.MESHPancreatic Neoplasms / surgery*-
dc.subject.MESHPancreaticoduodenectomy / methods*-
dc.subject.MESHPortal Vein / surgery*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate / trends-
dc.subject.MESHTime Factors-
dc.subject.MESHVascular Surgical Procedures / methods*-
dc.titleThe Impact of Neoadjuvant Treatment on Survival in Patients Undergoing Pancreatoduodenectomy With Concomitant Portomesenteric Venous Resection: An International Multicenter Analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorNikolaos Machairas-
dc.contributor.googleauthorDimitri A Raptis-
dc.contributor.googleauthorPatricia Sánchez Velázquez-
dc.contributor.googleauthorAlain Sauvanet-
dc.contributor.googleauthorAlexandra Rueda de Leon-
dc.contributor.googleauthorAtsushi Oba-
dc.contributor.googleauthorBas Groot Koerkamp-
dc.contributor.googleauthorBrendan Lovasik-
dc.contributor.googleauthorCarlos Chan-
dc.contributor.googleauthorCharles J Yeo-
dc.contributor.googleauthorClaudio Bassi-
dc.contributor.googleauthorCristina R Ferrone-
dc.contributor.googleauthorDavid Kooby-
dc.contributor.googleauthorDavid Moskal-
dc.contributor.googleauthorDomenico Tamburrino-
dc.contributor.googleauthorDong-Sup Yoon-
dc.contributor.googleauthorEduardo Barroso-
dc.contributor.googleauthorEduardo de Santibañes-
dc.contributor.googleauthorEmanuele F Kauffmann-
dc.contributor.googleauthorEmanuel Vigia-
dc.contributor.googleauthorFabien Robin-
dc.contributor.googleauthorFabio Casciani-
dc.contributor.googleauthorFernando Burdío-
dc.contributor.googleauthorGiulio Belfiori-
dc.contributor.googleauthorGiuseppe Malleo-
dc.contributor.googleauthorHarish Lavu-
dc.contributor.googleauthorHermien Hartog-
dc.contributor.googleauthorHo-Kyoung Hwang-
dc.contributor.googleauthorHo-Seong Han-
dc.contributor.googleauthorHugo P Marques-
dc.contributor.googleauthorIgnasi Poves-
dc.contributor.googleauthorIsmael Domínguez-Rosado-
dc.contributor.googleauthorJoon-Seong Park-
dc.contributor.googleauthorKeith D Lillemoe-
dc.contributor.googleauthorKeith Roberts-
dc.contributor.googleauthorLaurent Sulpice-
dc.contributor.googleauthorMarc G Besselink-
dc.contributor.googleauthorMahmoud Abuawwad-
dc.contributor.googleauthorMarco Del Chiaro-
dc.contributor.googleauthorMartin de Santibañes-
dc.contributor.googleauthorMassimo Falconi-
dc.contributor.googleauthorMizelle D'Silva-
dc.contributor.googleauthorMichael Silva-
dc.contributor.googleauthorMohammed Abu Hilal-
dc.contributor.googleauthorMotaz Qadan-
dc.contributor.googleauthorNaomi M Sell-
dc.contributor.googleauthorNassiba Beghdadi-
dc.contributor.googleauthorNiccolò Napoli-
dc.contributor.googleauthorOlivier R C Busch-
dc.contributor.googleauthorOscar Mazza-
dc.contributor.googleauthorPaolo Muiesan-
dc.contributor.googleauthorPhilip C Müller-
dc.contributor.googleauthorReena Ravikumar-
dc.contributor.googleauthorRichard Schulick-
dc.contributor.googleauthorSarah Powell-Brett-
dc.contributor.googleauthorSyed Hussain Abbas-
dc.contributor.googleauthorTara M Mackay-
dc.contributor.googleauthorThomas F Stoop-
dc.contributor.googleauthorTom K Gallagher-
dc.contributor.googleauthorUgo Boggi-
dc.contributor.googleauthorCasper van Eijck-
dc.contributor.googleauthorPierre-Alain Clavien-
dc.contributor.googleauthorKevin C P Conlon-
dc.contributor.googleauthorGiuseppe Kito Fusai-
dc.identifier.doi10.1097/SLA.0000000000005132-
dc.contributor.localIdA02548-
dc.contributor.localIdA04497-
dc.relation.journalcodeJ00178-
dc.identifier.eissn1528-1140 (-
dc.identifier.pmid34353988-
dc.identifier.urlhttps://journals.lww.com/annalsofsurgery/Fulltext/2021/11000/The_Impact_of_Neoadjuvant_Treatment_on_Survival_in.7.aspx-
dc.contributor.alternativeNameYoon, Dong Sup-
dc.contributor.affiliatedAuthor윤동섭-
dc.contributor.affiliatedAuthor황호경-
dc.citation.volume274-
dc.citation.number5-
dc.citation.startPage721-
dc.citation.endPage728-
dc.identifier.bibliographicCitationANNALS OF SURGERY, Vol.274(5) : 721-728, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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