Cited 23 times in
The Impact of Neoadjuvant Treatment on Survival in Patients Undergoing Pancreatoduodenectomy With Concomitant Portomesenteric Venous Resection: An International Multicenter Analysis
DC Field | Value | Language |
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dc.contributor.author | 윤동섭 | - |
dc.contributor.author | 황호경 | - |
dc.contributor.author | 박준성 | - |
dc.date.accessioned | 2022-02-23T01:11:57Z | - |
dc.date.available | 2022-02-23T01:11:57Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 0003-4932 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187581 | - |
dc.description.abstract | Objective: The aim of this study was to evaluate whether neoadjuvant therapy (NAT) critically influenced microscopically complete resection (R0) rates and long-term outcomes for patients with pancreatic ductal adenocarcinoma who underwent pancreatoduodenectomy (PD) with portomesenteric vein resection (PVR) from a diverse, world-wide group of high-volume centers. Summary of background data: Limited size studies suggest that NAT improves R0 rates and overall survival compared to upfront surgery in R/BR-PDAC patients. Methods: This multicenter study analyzed consecutive patients with R/BR-PDAC who underwent PD with PVR in 23 high-volume centers from 2009 to 2018. Results: Data from 1192 patients with PD and PVR were collected and analyzed. The median age was 68 [interquartile range (IQR) 60-73] years and 52% were males. Some 186 (15.6%) and 131 (10.9%) patients received neoadjuvant chemotherapy (NAC) alone and neoadjuvant chemoradiotherapy, respectively. The R0/R1/R2 rates were 57%, 39.3%, and 3.2% in patients who received NAT compared to 46.6%, 49.9%, and 3.5% in patients who did not, respectively (P =0.004). The 1-, 3-, and 5-year OS in patients receiving NAT was 79%, 41%, and 29%, while for those that did not it was 73%, 29%, and 18%, respectively (P <0.001). Multivariable analysis showed no administration of NAT, high tumor grade, lymphovascular invasion, R1/R2 resection, no adjuvant chemotherapy, occurrence of Clavien-Dindo grade 3 or higher postoperative complications within 90 days, preoperative diabetes mellitus, male sex and portal vein involvement were negative independent predictive factors for OS. Conclusion: Patients with PDAC of the pancreatic head expected to undergo venous reconstruction should routinely be considered for NAT. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | ANNALS OF SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Europe / epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mesenteric Veins / surgery* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoadjuvant Therapy | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Pancreas / blood supply* | - |
dc.subject.MESH | Pancreas / surgery | - |
dc.subject.MESH | Pancreatic Neoplasms / blood supply | - |
dc.subject.MESH | Pancreatic Neoplasms / mortality | - |
dc.subject.MESH | Pancreatic Neoplasms / surgery* | - |
dc.subject.MESH | Pancreaticoduodenectomy / methods* | - |
dc.subject.MESH | Portal Vein / surgery* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate / trends | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Vascular Surgical Procedures / methods* | - |
dc.title | The Impact of Neoadjuvant Treatment on Survival in Patients Undergoing Pancreatoduodenectomy With Concomitant Portomesenteric Venous Resection: An International Multicenter Analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Nikolaos Machairas | - |
dc.contributor.googleauthor | Dimitri A Raptis | - |
dc.contributor.googleauthor | Patricia Sánchez Velázquez | - |
dc.contributor.googleauthor | Alain Sauvanet | - |
dc.contributor.googleauthor | Alexandra Rueda de Leon | - |
dc.contributor.googleauthor | Atsushi Oba | - |
dc.contributor.googleauthor | Bas Groot Koerkamp | - |
dc.contributor.googleauthor | Brendan Lovasik | - |
dc.contributor.googleauthor | Carlos Chan | - |
dc.contributor.googleauthor | Charles J Yeo | - |
dc.contributor.googleauthor | Claudio Bassi | - |
dc.contributor.googleauthor | Cristina R Ferrone | - |
dc.contributor.googleauthor | David Kooby | - |
dc.contributor.googleauthor | David Moskal | - |
dc.contributor.googleauthor | Domenico Tamburrino | - |
dc.contributor.googleauthor | Dong-Sup Yoon | - |
dc.contributor.googleauthor | Eduardo Barroso | - |
dc.contributor.googleauthor | Eduardo de Santibañes | - |
dc.contributor.googleauthor | Emanuele F Kauffmann | - |
dc.contributor.googleauthor | Emanuel Vigia | - |
dc.contributor.googleauthor | Fabien Robin | - |
dc.contributor.googleauthor | Fabio Casciani | - |
dc.contributor.googleauthor | Fernando Burdío | - |
dc.contributor.googleauthor | Giulio Belfiori | - |
dc.contributor.googleauthor | Giuseppe Malleo | - |
dc.contributor.googleauthor | Harish Lavu | - |
dc.contributor.googleauthor | Hermien Hartog | - |
dc.contributor.googleauthor | Ho-Kyoung Hwang | - |
dc.contributor.googleauthor | Ho-Seong Han | - |
dc.contributor.googleauthor | Hugo P Marques | - |
dc.contributor.googleauthor | Ignasi Poves | - |
dc.contributor.googleauthor | Ismael Domínguez-Rosado | - |
dc.contributor.googleauthor | Joon-Seong Park | - |
dc.contributor.googleauthor | Keith D Lillemoe | - |
dc.contributor.googleauthor | Keith Roberts | - |
dc.contributor.googleauthor | Laurent Sulpice | - |
dc.contributor.googleauthor | Marc G Besselink | - |
dc.contributor.googleauthor | Mahmoud Abuawwad | - |
dc.contributor.googleauthor | Marco Del Chiaro | - |
dc.contributor.googleauthor | Martin de Santibañes | - |
dc.contributor.googleauthor | Massimo Falconi | - |
dc.contributor.googleauthor | Mizelle D'Silva | - |
dc.contributor.googleauthor | Michael Silva | - |
dc.contributor.googleauthor | Mohammed Abu Hilal | - |
dc.contributor.googleauthor | Motaz Qadan | - |
dc.contributor.googleauthor | Naomi M Sell | - |
dc.contributor.googleauthor | Nassiba Beghdadi | - |
dc.contributor.googleauthor | Niccolò Napoli | - |
dc.contributor.googleauthor | Olivier R C Busch | - |
dc.contributor.googleauthor | Oscar Mazza | - |
dc.contributor.googleauthor | Paolo Muiesan | - |
dc.contributor.googleauthor | Philip C Müller | - |
dc.contributor.googleauthor | Reena Ravikumar | - |
dc.contributor.googleauthor | Richard Schulick | - |
dc.contributor.googleauthor | Sarah Powell-Brett | - |
dc.contributor.googleauthor | Syed Hussain Abbas | - |
dc.contributor.googleauthor | Tara M Mackay | - |
dc.contributor.googleauthor | Thomas F Stoop | - |
dc.contributor.googleauthor | Tom K Gallagher | - |
dc.contributor.googleauthor | Ugo Boggi | - |
dc.contributor.googleauthor | Casper van Eijck | - |
dc.contributor.googleauthor | Pierre-Alain Clavien | - |
dc.contributor.googleauthor | Kevin C P Conlon | - |
dc.contributor.googleauthor | Giuseppe Kito Fusai | - |
dc.identifier.doi | 10.1097/SLA.0000000000005132 | - |
dc.contributor.localId | A02548 | - |
dc.contributor.localId | A04497 | - |
dc.relation.journalcode | J00178 | - |
dc.identifier.eissn | 1528-1140 ( | - |
dc.identifier.pmid | 34353988 | - |
dc.identifier.url | https://journals.lww.com/annalsofsurgery/Fulltext/2021/11000/The_Impact_of_Neoadjuvant_Treatment_on_Survival_in.7.aspx | - |
dc.contributor.alternativeName | Yoon, Dong Sup | - |
dc.contributor.affiliatedAuthor | 윤동섭 | - |
dc.contributor.affiliatedAuthor | 황호경 | - |
dc.citation.volume | 274 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 721 | - |
dc.citation.endPage | 728 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGERY, Vol.274(5) : 721-728, 2021-11 | - |
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