Cited 2 times in
Tacrolimus trough levels in kidney transplant recipients
DC Field | Value | Language |
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dc.contributor.author | 양재석 | - |
dc.date.accessioned | 2022-02-23T01:00:10Z | - |
dc.date.available | 2022-02-23T01:00:10Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187490 | - |
dc.description.abstract | Background: It is very important that kidney transplant recipients (KTRs) take immunosuppressive drugs to prevent graft rejection. This study aimed to identify the tacrolimus trough levels (TTL)-mean, TTL-standard deviation (SD), and TTL- coefficient of variation (CV) as well as factors affecting these values over a 2-year period in clinically stable patients > 5 years after kidney transplantation (KT). Methods: This retrospective study analyzed data from 248 adult outpatients > 5 years after KT. Medical chart data, including TTL, graft rejection, and tacrolimus dose change during a 2-year period, between January 2017 and December 2018, were collected. Multivariable regression analyses were conducted to determine the factors influencing the TTL-mean, TTL-SD, and TTL-CV. Results: The TTL-mean, TTL-SD, and TTL-CV were 6.00 ± 1.07 ng/mL, 1.51 ± 1.09 ng/mL, and 0.25 ± 0.14, respectively. The TTL-mean, TTL-SD, and TTL-CV did not differ according to sex, type of donor, retransplant, pretransplant kidney disease, body mass index, or posttransplant time; hence, they are stable in kidney transplant recipients > 5 years after KT. The higher the TTL-mean, the higher the TTL-SD. Age and the TTL-SD significantly predicted the TTL-mean (p < .001). Tacrolimus dose change and the TTL-mean significantly predicted the TTL-SD (p < .001). Tacrolimus dose change significantly predicted the TTL-CV (p = .008). Conclusion: In clinically stable KTRs, TTL-SD and TTL-CV change sensitively in relation to tacrolimus dose changes. Therefore, changes in TTL-SD and TTL-CV in stable KTRs with no tacrolimus dose change require medical interest and attention. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Tacrolimus trough levels in kidney transplant recipients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Young Hui Hwang | - |
dc.contributor.googleauthor | Hyunjung Kim | - |
dc.contributor.googleauthor | Kyungok Min | - |
dc.contributor.googleauthor | Jaeseok Yang | - |
dc.identifier.doi | 10.1186/s12882-021-02622-5 | - |
dc.contributor.localId | A06130 | - |
dc.relation.journalcode | J00367 | - |
dc.identifier.eissn | 1471-2369 | - |
dc.identifier.pmid | 34876046 | - |
dc.subject.keyword | Coefficient of variation | - |
dc.subject.keyword | Mean | - |
dc.subject.keyword | Medication adherence | - |
dc.subject.keyword | Standard deviation | - |
dc.subject.keyword | Tacrolimus trough level | - |
dc.contributor.alternativeName | Yang, Jaeseok | - |
dc.contributor.affiliatedAuthor | 양재석 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 405 | - |
dc.identifier.bibliographicCitation | BMC NEPHROLOGY, Vol.22(1) : 405, 2021-12 | - |
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