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Association between pancreatic fibrosis and development of pancreoprivic diabetes after pancreaticoduodenectomy

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dc.contributor.author강신애-
dc.contributor.author김형선-
dc.contributor.author남지해-
dc.contributor.author박준성-
dc.contributor.author이민영-
dc.contributor.author이정민-
dc.date.accessioned2022-02-23T00:55:25Z-
dc.date.available2022-02-23T00:55:25Z-
dc.date.issued2021-12-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187443-
dc.description.abstractThis study investigated the correlation between pancreatic fibrosis (PF) and development of pancreoprivic diabetes after pancreaticoduodenectomy (PD). Ninety-five patients who underwent PD at Gangnam Severance Hospital between 2014 and 2017 were enrolled. PF grade was evaluated with alpha-smooth muscle actin (SMA) and Masson's trichrome (TRC) staining. New-onset pancreoprivic diabetes and recurrence of disease were evaluated using fasting blood glucose measurement and radiography taken at 3-month intervals. Sixty-one patients did not have preoperative diabetes, however, 40 (65.6%) patients developed pancreoprivic diabetes after PD. High-grade PF was more common in the diabetes group than in the normal group (SMA, 42.5% vs. 28.6%, P = 0.747; TRC, 47.5% vs. 28.6%, P = 0.361). The 1-year cumulative incidence of hyperglycemia/pancreoprivic diabetes was higher with high-grade PF than low-grade PF (SMA, 94.4% vs. 73.0%, P = 0.027; TRC, 89.3% vs. 75.0%, P = 0.074). The SMA-TRC combined high-grade group had a higher proportion of primary pancreatic disease than the combined low-grade group (90.0% vs. 37.5%, P = 0.001). The 5-year disease-free survival of patients with pancreatic cancer was worse with high-grade PF than low-grade PF (SMA, 24.5% vs. 66.3%, P = 0.026; TRC, 23.6% vs. 58.4%, P = 0.047). In conclusion, patients with severe PF are more likely to develop pancreoprivic diabetes after PD and have worse disease-free survival.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBlood Glucose / metabolism-
dc.subject.MESHDiabetes Mellitus / etiology*-
dc.subject.MESHDiabetes Mellitus / metabolism-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHFibrosis / complications*-
dc.subject.MESHFibrosis / metabolism-
dc.subject.MESHFibrosis / surgery*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPancreas / metabolism-
dc.subject.MESHPancreas / surgery-
dc.subject.MESHPancreatic Diseases / complications*-
dc.subject.MESHPancreatic Diseases / metabolism-
dc.subject.MESHPancreatic Diseases / surgery*-
dc.subject.MESHPancreaticoduodenectomy / adverse effects*-
dc.titleAssociation between pancreatic fibrosis and development of pancreoprivic diabetes after pancreaticoduodenectomy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJung Min Lee-
dc.contributor.googleauthorHyung Sun Kim-
dc.contributor.googleauthorMinyoung Lee-
dc.contributor.googleauthorHo Seon Park-
dc.contributor.googleauthorShinae Kang-
dc.contributor.googleauthorJi Hae Nahm-
dc.contributor.googleauthorJoon Seong Park-
dc.identifier.doi10.1038/s41598-021-02858-z-
dc.contributor.localIdA00052-
dc.contributor.localIdA04552-
dc.contributor.localIdA05120-
dc.contributor.localIdA01672-
dc.contributor.localIdA05491-
dc.contributor.localIdA06214-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid34876608-
dc.contributor.alternativeNameKang, Shin Ae-
dc.contributor.affiliatedAuthor강신애-
dc.contributor.affiliatedAuthor김형선-
dc.contributor.affiliatedAuthor남지해-
dc.contributor.affiliatedAuthor박준성-
dc.contributor.affiliatedAuthor이민영-
dc.contributor.affiliatedAuthor이정민-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage23538-
dc.citation.endPage1-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 23538-1, 2021-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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