Cited 4 times in
Besifovir dipivoxil maleate: a novel antiviral agent with low toxicity and high genetic barriers for chronic hepatitis B
DC Field | Value | Language |
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dc.contributor.author | 박준용 | - |
dc.date.accessioned | 2022-02-23T00:54:59Z | - |
dc.date.available | 2022-02-23T00:54:59Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1465-6566 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187438 | - |
dc.description.abstract | Introduction: Chronic hepatitis B is an important public health concern. Introduction of oral nucleos(t)ide analogs (NAs), inhibitors of hepatitis B virus (HBV) polymerase, was a milestone that lowered the high viral loads associated with an increased risk of liver-related complications. Areas covered: Although the currently available NAs are effective in suppressing viral replication, anti-HBV treatment in principle requires lifelong drug administration, and some patients have limitations such as the incidence of liver cancer and the likelihood of toxicities following long-term treatment despite viral suppression. Besifovir dipivoxil maleate (BSV), an oral nucleotide analog, is a prodrug that is metabolized to its active form. It has consistent and well-characterized pharmacokinetics in animals and human. In clinical studies, BSV exhibits significant and potent viral suppression of HBV replication with maintenance of antiviral efficacy for over 192 weeks without resistance, or renal and bone toxicities. Herein, the authors discuss the data of BSV and provide the reader with their expert opinion. Expert opinion: BSV is a newly developed antiviral agent against HBV. This new agent has strong antiviral activity with low toxicity and a high barrier to resistance. Because there is concern that patients treated with a high dose of BSV require carnitine supplementation, BSV with carnitine supplementation is recommended during antiviral therapy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | EXPERT OPINION ON PHARMACOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antiviral Agents / adverse effects | - |
dc.subject.MESH | Guanine / analogs & derivatives | - |
dc.subject.MESH | Hepatitis B virus / genetics | - |
dc.subject.MESH | Hepatitis B, Chronic* / drug therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Maleates / therapeutic use | - |
dc.subject.MESH | Organophosphonates* / therapeutic use | - |
dc.title | Besifovir dipivoxil maleate: a novel antiviral agent with low toxicity and high genetic barriers for chronic hepatitis B | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jeong Eun Song | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.identifier.doi | 10.1080/14656566.2021.1967321 | - |
dc.contributor.localId | A01675 | - |
dc.relation.journalcode | J04156 | - |
dc.identifier.eissn | 1744-7666 | - |
dc.identifier.pmid | 34392744 | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/14656566.2021.1967321 | - |
dc.subject.keyword | Besifovir dipivoxil maleate | - |
dc.subject.keyword | antiviral efficacy | - |
dc.subject.keyword | bone toxicity | - |
dc.subject.keyword | carnitine | - |
dc.subject.keyword | hepatitis B virus | - |
dc.subject.keyword | renal toxicity | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | 박준용 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 2427 | - |
dc.citation.endPage | 2433 | - |
dc.identifier.bibliographicCitation | EXPERT OPINION ON PHARMACOTHERAPY, Vol.22(18) : 2427-2433, 2021-12 | - |
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