Cited 37 times in
Estimating COVID-19 Infection and Severity Risks in Patients with Chronic Rhinosinusitis: A Korean Nationwide Cohort Study
DC Field | Value | Language |
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dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2022-01-26T01:55:00Z | - |
dc.date.available | 2022-01-26T01:55:00Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2213-2198 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187375 | - |
dc.description.abstract | Background: Basic studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can affect chronic rhinosinusitis (CRS), but there is unclear real-world evidence regarding the association of underlying CRS with the risk for SARS-CoV-2 infection and severe coronavirus disease 19 (COVID-19). Objective: We aimed to determine whether CRS is associated with increased risk for SARS-CoV-2 infection and severe COVID-19. Methods: Altogether, 219,959 adult patients who tested for SARS-CoV-2 in South Korea from January 1 to May 15, 2020 (excluding self-referral) were identified in this nested case-control study with propensity score matching. Data on SARS-CoV-2 test results and COVID-19 worsened outcomes (ie, the need for oxygen therapy, intensive care, or mechanical ventilation, and death) were obtained from the Health Insurance Review and Assessment Service of Korea. Results: In this matched cohort, 380 of 12,217 patients with CRS (3.1%) tested positive for SARS-CoV-2 infection, compared with 310 patients without CRS (2.5%; adjusted odds ratio = 1.22; 95% confidence interval, 1.04-1.42). Moreover, 60 of 286 COVID-19 patients with CRS (21.0%) had severe COVID-19 outcomes, compared with 38 without CRS (13.3%; adjusted odds ratio = 1.71; 95% confidence interval, 1.09-2.71). Subgroup analysis identified that CRS patients with an absence of nasal polyps, prior intranasal corticosteroid use, or nonatopic type had a greater risk for SARS-CoV-2 infection and severe COVID-19 outcomes. Conclusions: In patients with CRS, prior intranasal corticosteroid use, the absence of nasal polyps, or nonatopic type was associated with increased risk for SARS-CoV-2 infection and severe COVID-19 in the Korean nationwide cohort. Clinicians should be cautious in determining prognosis and care for patients with CRS amid the COVID-19 pandemic. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | COVID-19* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Pandemics* | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | SARS-CoV-2 | - |
dc.title | Estimating COVID-19 Infection and Severity Risks in Patients with Chronic Rhinosinusitis: A Korean Nationwide Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Seung Won Lee | - |
dc.contributor.googleauthor | So Young Kim | - |
dc.contributor.googleauthor | Sung Yong Moon | - |
dc.contributor.googleauthor | Jee Myung Yang | - |
dc.contributor.googleauthor | Eun Kyo Ha | - |
dc.contributor.googleauthor | Hye Mi Jee | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Seong Ho Cho | - |
dc.contributor.googleauthor | Dong Keon Yon | - |
dc.contributor.googleauthor | Dong In Suh | - |
dc.identifier.doi | 10.1016/j.jaip.2021.03.044 | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J03352 | - |
dc.identifier.eissn | 2213-2201 | - |
dc.identifier.pmid | 33931377 | - |
dc.subject.keyword | COVID-19 | - |
dc.subject.keyword | Chronic rhinosinusitis | - |
dc.subject.keyword | Intranasal corticosteroids | - |
dc.subject.keyword | Nasal polyp | - |
dc.subject.keyword | Severe acute respiratory syndrome 2. | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2262 | - |
dc.citation.endPage | 2271 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, Vol.9(6) : 2262-2271, 2021-06 | - |
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