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Comparing Treatment Outcomes of Ampicillin-Sulbactam, Other β-Lactams, and Vancomycin in Blood Culture-Negative Infective Endocarditis
DC Field | Value | Language |
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dc.contributor.author | 구남수 | - |
dc.contributor.author | 김정호 | - |
dc.contributor.author | 김진남 | - |
dc.contributor.author | 백예지 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 안진영 | - |
dc.contributor.author | 염준섭 | - |
dc.contributor.author | 이기현 | - |
dc.contributor.author | 이세주 | - |
dc.contributor.author | 이승현 | - |
dc.contributor.author | 이은화 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2021-12-28T17:54:40Z | - |
dc.date.available | 2021-12-28T17:54:40Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187327 | - |
dc.description.abstract | Selection of proper antibiotics for blood culture-negative infective endocarditis (BCNIE) is difficult due to limited data on antibiotic regimens for BCNIE in existing literature. The aim of this study was to compare ampicillin-sulbactam, other β-lactams antibiotics, and vancomycin among patients with BCNIE to determine the proper antibiotic regimens. This retrospective study included adult patients with BCNIE admitted to Severance Hospital from November 2005 to August 2017. Patients were classified into three groups as, treated with ampicillin-sulbactam, other β-lactams, and vancomycin. The primary outcome was 1-year all-cause mortality. A total of 74 cases with BCNIE were enrolled in this study. There were no statistically significant differences in clinical characteristics between the three groups. One-year mortality did not significantly differ between the study groups either. Further, in-hospital mortality, 28-day mortality and overall mortality showed no difference. However, Cox-regression analysis showed nosocomial infective endocarditis as an independent risk factor and a protective effect of surgery on 1-year mortality. This study showed no clear difference in the outcomes of BCNIE as per the antibiotic therapy but suggested the beneficial effect of surgical treatment. With increasing global concern of antimicrobial resistance, it might be reasonable to select ampicillin-sulbactam-based antibiotic therapy while actively considering surgical treatment in BCNIE. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.relation.isPartOf | ANTIBIOTICS-BASEL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Comparing Treatment Outcomes of Ampicillin-Sulbactam, Other β-Lactams, and Vancomycin in Blood Culture-Negative Infective Endocarditis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Se Ju Lee | - |
dc.contributor.googleauthor | Jung Ho Kim | - |
dc.contributor.googleauthor | Hi Jae Lee | - |
dc.contributor.googleauthor | Ki Hyun Lee | - |
dc.contributor.googleauthor | Eun Hwa Lee | - |
dc.contributor.googleauthor | Yae Jee Baek | - |
dc.contributor.googleauthor | Jin Nam Kim | - |
dc.contributor.googleauthor | Jin Young Ahn | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Nam Su Ku | - |
dc.contributor.googleauthor | Seung Hyun Lee | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Joon Sup Yeom | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.identifier.doi | 10.3390/antibiotics10121476 | - |
dc.contributor.localId | A00189 | - |
dc.contributor.localId | A00902 | - |
dc.contributor.localId | A05112 | - |
dc.contributor.localId | A05921 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A02267 | - |
dc.contributor.localId | A02353 | - |
dc.contributor.localId | A06174 | - |
dc.contributor.localId | A05162 | - |
dc.contributor.localId | A02935 | - |
dc.contributor.localId | A06176 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J03862 | - |
dc.identifier.eissn | 2079-6382 | - |
dc.subject.keyword | antibiotics | - |
dc.subject.keyword | blood culture-negative infective endocarditis | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | risk factors | - |
dc.contributor.alternativeName | Ku, Nam Su | - |
dc.contributor.affiliatedAuthor | 구남수 | - |
dc.contributor.affiliatedAuthor | 김정호 | - |
dc.contributor.affiliatedAuthor | 김진남 | - |
dc.contributor.affiliatedAuthor | 백예지 | - |
dc.contributor.affiliatedAuthor | 송영구 | - |
dc.contributor.affiliatedAuthor | 안진영 | - |
dc.contributor.affiliatedAuthor | 염준섭 | - |
dc.contributor.affiliatedAuthor | 이기현 | - |
dc.contributor.affiliatedAuthor | 이세주 | - |
dc.contributor.affiliatedAuthor | 이승현 | - |
dc.contributor.affiliatedAuthor | 이은화 | - |
dc.contributor.affiliatedAuthor | 정수진 | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1476 | - |
dc.identifier.bibliographicCitation | ANTIBIOTICS-BASEL, Vol.10(12) : 1476, 2021-12 | - |
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