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Dialysis Adequacy and Risk of Dementia in Elderly Hemodialysis Patients

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dc.contributor.author강신욱-
dc.contributor.author김형우-
dc.contributor.author박정탁-
dc.contributor.author유태현-
dc.contributor.author주영수-
dc.contributor.author지종현-
dc.contributor.author한승혁-
dc.date.accessioned2021-12-28T17:54:23Z-
dc.date.available2021-12-28T17:54:23Z-
dc.date.issued2021-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187325-
dc.description.abstractObjective: Dementia is prevalent among elderly patients undergoing hemodialysis. However, the association between dialysis adequacy and the risk of dementia is uncertain. Methods: A total of 10,567 patients aged >65 years undergoing maintenance hemodialysis who participated in a national hemodialysis quality assessment program were analyzed. The patients were classified into quartile groups based on single-pool Kt/V levels. The associations between single-pool Kt/V and the development of dementia, Alzheimer's disease (AD), and vascular dementia (VD) were examined. Results: The mean age of the patients was 72.9 years, and 43.4% were female. The mean baseline single-pool Kt/V level was 1.6 ± 0.3. During a median follow-up of 45.6 (45.6–69.9) months, there were 27.6, 23.9, and 2.8 events/1,000 person-years of overall dementia, AD, and VD, respectively. The incidences of overall dementia, AD, and VD were lowest in the highest single-pool Kt/V quartile group. Compared with the lowest single-pool Kt/V quartile, the risks of incident overall dementia and AD were significantly lower in the highest quartile [sub-distribution hazard ratio (sHR): 0.69, 95% confidence interval (CI): 0.58–0.82 for overall dementia; sHR: 0.69, 95% CI: 0.57–0.84 for AD]. Inverse relationships were found between the risks of developing overall dementia and AD, and single-pool Kt/V. However, no significant relationship was observed between single-pool Kt/V levels and VD development. Conclusions: Increased dialysis clearance was associated with a lower risk of developing dementia in elderly hemodialysis patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Media S.A.-
dc.relation.isPartOfFRONTIERS IN MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDialysis Adequacy and Risk of Dementia in Elderly Hemodialysis Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHyung Woo Kim-
dc.contributor.googleauthorJong Hyun Jhee-
dc.contributor.googleauthorYoung Su Joo-
dc.contributor.googleauthorKi Hwa Yang-
dc.contributor.googleauthorJin Ju Jung-
dc.contributor.googleauthorJi Hyeon Shin-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorJung Tak Park-
dc.identifier.doi10.3389/fmed.2021.769490-
dc.contributor.localIdA00053-
dc.contributor.localIdA01151-
dc.contributor.localIdA01654-
dc.contributor.localIdA02526-
dc.contributor.localIdA03956-
dc.contributor.localIdA03970-
dc.contributor.localIdA04304-
dc.relation.journalcodeJ03762-
dc.identifier.eissn2296-858X-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthor강신욱-
dc.contributor.affiliatedAuthor김형우-
dc.contributor.affiliatedAuthor박정탁-
dc.contributor.affiliatedAuthor유태현-
dc.contributor.affiliatedAuthor주영수-
dc.contributor.affiliatedAuthor지종현-
dc.contributor.affiliatedAuthor한승혁-
dc.citation.volume8-
dc.citation.startPage769490-
dc.identifier.bibliographicCitationFRONTIERS IN MEDICINE, Vol.8 : 769490, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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