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Dialysis Adequacy and Risk of Dementia in Elderly Hemodialysis Patients
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.contributor.author | 김형우 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 주영수 | - |
dc.contributor.author | 지종현 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2021-12-28T17:54:23Z | - |
dc.date.available | 2021-12-28T17:54:23Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187325 | - |
dc.description.abstract | Objective: Dementia is prevalent among elderly patients undergoing hemodialysis. However, the association between dialysis adequacy and the risk of dementia is uncertain. Methods: A total of 10,567 patients aged >65 years undergoing maintenance hemodialysis who participated in a national hemodialysis quality assessment program were analyzed. The patients were classified into quartile groups based on single-pool Kt/V levels. The associations between single-pool Kt/V and the development of dementia, Alzheimer's disease (AD), and vascular dementia (VD) were examined. Results: The mean age of the patients was 72.9 years, and 43.4% were female. The mean baseline single-pool Kt/V level was 1.6 ± 0.3. During a median follow-up of 45.6 (45.6–69.9) months, there were 27.6, 23.9, and 2.8 events/1,000 person-years of overall dementia, AD, and VD, respectively. The incidences of overall dementia, AD, and VD were lowest in the highest single-pool Kt/V quartile group. Compared with the lowest single-pool Kt/V quartile, the risks of incident overall dementia and AD were significantly lower in the highest quartile [sub-distribution hazard ratio (sHR): 0.69, 95% confidence interval (CI): 0.58–0.82 for overall dementia; sHR: 0.69, 95% CI: 0.57–0.84 for AD]. Inverse relationships were found between the risks of developing overall dementia and AD, and single-pool Kt/V. However, no significant relationship was observed between single-pool Kt/V levels and VD development. Conclusions: Increased dialysis clearance was associated with a lower risk of developing dementia in elderly hemodialysis patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Media S.A. | - |
dc.relation.isPartOf | FRONTIERS IN MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Dialysis Adequacy and Risk of Dementia in Elderly Hemodialysis Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyung Woo Kim | - |
dc.contributor.googleauthor | Jong Hyun Jhee | - |
dc.contributor.googleauthor | Young Su Joo | - |
dc.contributor.googleauthor | Ki Hwa Yang | - |
dc.contributor.googleauthor | Jin Ju Jung | - |
dc.contributor.googleauthor | Ji Hyeon Shin | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.identifier.doi | 10.3389/fmed.2021.769490 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A01151 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A03956 | - |
dc.contributor.localId | A03970 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J03762 | - |
dc.identifier.eissn | 2296-858X | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 김형우 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 주영수 | - |
dc.contributor.affiliatedAuthor | 지종현 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 8 | - |
dc.citation.startPage | 769490 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN MEDICINE, Vol.8 : 769490, 2021-11 | - |
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