Cited 0 times in
Early Diagnostic Ability of Human Complement Factor B in Pancreatic Cancer Is Partly Linked to Its Potential Tumor-Promoting Role
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강창무 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 이충근 | - |
dc.contributor.author | 최혜진 | - |
dc.contributor.author | 김성현 | - |
dc.date.accessioned | 2021-12-28T17:54:14Z | - |
dc.date.available | 2021-12-28T17:54:14Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1535-3893 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187324 | - |
dc.description.abstract | Although plasma complement factor B (CFB, NX_P00751), both alone and in combination with CA19-9 (i.e., the ComB-CAN), previously exhibited a reliable diagnostic ability for pancreatic cancer (PC), its detectability of the early stages and the cancer detection mechanism remained elusive. We first evaluated the diagnostic accuracy of ComB-CAN using plasma samples from healthy donors (HDs), patients with chronic pancreatitis (CP), and patients with different PC stages (I/II vs III/IV). An analysis of the area under the curve (AUC) by PanelComposer using logistic regression revealed that ComB-CAN has a superior diagnostic ability for early-stage PC (97.1.% [95% confidence interval (CI): (97.1-97.2)]) compared with CFB (94.3% [95% CI: 94.2-94.4]) or CA19-9 alone (34.3% [95% CI: 34.1-34.4]). In the comparisons of all stages of patients with PC vs CP and HDs, the AUC values of ComB-CAN, CFB, and CA19-9 were 0.983 (95% CI: 0.983-0.983), 0.950 (95% CI: 0.950-0.951), and 0.873 (95% CI: 0.873-0.874), respectively. We then investigated the molecular mechanism underlying the detection of early-stage PC by using stable cell lines of CFB knockdown and CFB overexpression. A global transcriptomic analysis coupled to cell invasion assays of both CFB-modulated cell lines suggested that CFB plays a tumor-promoting role in PC, which likely initiates the PI3K-AKT cancer signaling pathway. Thus our study establishes ComB-CAN as a reliable early diagnostic marker for PC that can be clinically applied for early PC screening in the general public. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | JOURNAL OF PROTEOME RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Early Diagnostic Ability of Human Complement Factor B in Pancreatic Cancer Is Partly Linked to Its Potential Tumor-Promoting Role | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Min Jung Lee | - |
dc.contributor.googleauthor | Keun Na | - |
dc.contributor.googleauthor | Heon Shin | - |
dc.contributor.googleauthor | Chae-Yeon Kim | - |
dc.contributor.googleauthor | Jin-Young Cho | - |
dc.contributor.googleauthor | Chang Moo Kang | - |
dc.contributor.googleauthor | Sung Hyun Kim | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Hye Jin Choi | - |
dc.contributor.googleauthor | Choong-Kun Lee | - |
dc.contributor.googleauthor | Sumi Bae | - |
dc.contributor.googleauthor | Sunghwa Son | - |
dc.contributor.googleauthor | Young-Ki Paik | - |
dc.identifier.doi | 10.1021/acs.jproteome.1c00805 | - |
dc.contributor.localId | A00088 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A03259 | - |
dc.contributor.localId | A04219 | - |
dc.relation.journalcode | J01720 | - |
dc.identifier.eissn | 1535-3907 | - |
dc.identifier.pmid | 34766501 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acs.jproteome.1c00805 | - |
dc.subject.keyword | CA-19-9 | - |
dc.subject.keyword | ComB-CAN | - |
dc.subject.keyword | PDAC | - |
dc.subject.keyword | complement factor B | - |
dc.subject.keyword | early detection | - |
dc.subject.keyword | pancreatic cancer | - |
dc.subject.keyword | tumor promotion | - |
dc.contributor.alternativeName | Kang, Chang Moo | - |
dc.contributor.affiliatedAuthor | 강창무 | - |
dc.contributor.affiliatedAuthor | 김호근 | - |
dc.contributor.affiliatedAuthor | 이충근 | - |
dc.contributor.affiliatedAuthor | 최혜진 | - |
dc.citation.volume | 20 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 5315 | - |
dc.citation.endPage | 5328 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PROTEOME RESEARCH, Vol.20(12) : 5315-5328, 2021-12 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.