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Early Diagnostic Ability of Human Complement Factor B in Pancreatic Cancer Is Partly Linked to Its Potential Tumor-Promoting Role

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dc.contributor.author강창무-
dc.contributor.author김호근-
dc.contributor.author이충근-
dc.contributor.author최혜진-
dc.contributor.author김성현-
dc.date.accessioned2021-12-28T17:54:14Z-
dc.date.available2021-12-28T17:54:14Z-
dc.date.issued2021-12-
dc.identifier.issn1535-3893-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187324-
dc.description.abstractAlthough plasma complement factor B (CFB, NX_P00751), both alone and in combination with CA19-9 (i.e., the ComB-CAN), previously exhibited a reliable diagnostic ability for pancreatic cancer (PC), its detectability of the early stages and the cancer detection mechanism remained elusive. We first evaluated the diagnostic accuracy of ComB-CAN using plasma samples from healthy donors (HDs), patients with chronic pancreatitis (CP), and patients with different PC stages (I/II vs III/IV). An analysis of the area under the curve (AUC) by PanelComposer using logistic regression revealed that ComB-CAN has a superior diagnostic ability for early-stage PC (97.1.% [95% confidence interval (CI): (97.1-97.2)]) compared with CFB (94.3% [95% CI: 94.2-94.4]) or CA19-9 alone (34.3% [95% CI: 34.1-34.4]). In the comparisons of all stages of patients with PC vs CP and HDs, the AUC values of ComB-CAN, CFB, and CA19-9 were 0.983 (95% CI: 0.983-0.983), 0.950 (95% CI: 0.950-0.951), and 0.873 (95% CI: 0.873-0.874), respectively. We then investigated the molecular mechanism underlying the detection of early-stage PC by using stable cell lines of CFB knockdown and CFB overexpression. A global transcriptomic analysis coupled to cell invasion assays of both CFB-modulated cell lines suggested that CFB plays a tumor-promoting role in PC, which likely initiates the PI3K-AKT cancer signaling pathway. Thus our study establishes ComB-CAN as a reliable early diagnostic marker for PC that can be clinically applied for early PC screening in the general public.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Chemical Society-
dc.relation.isPartOfJOURNAL OF PROTEOME RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEarly Diagnostic Ability of Human Complement Factor B in Pancreatic Cancer Is Partly Linked to Its Potential Tumor-Promoting Role-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorMin Jung Lee-
dc.contributor.googleauthorKeun Na-
dc.contributor.googleauthorHeon Shin-
dc.contributor.googleauthorChae-Yeon Kim-
dc.contributor.googleauthorJin-Young Cho-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorSung Hyun Kim-
dc.contributor.googleauthorHoguen Kim-
dc.contributor.googleauthorHye Jin Choi-
dc.contributor.googleauthorChoong-Kun Lee-
dc.contributor.googleauthorSumi Bae-
dc.contributor.googleauthorSunghwa Son-
dc.contributor.googleauthorYoung-Ki Paik-
dc.identifier.doi10.1021/acs.jproteome.1c00805-
dc.contributor.localIdA00088-
dc.contributor.localIdA01183-
dc.contributor.localIdA03259-
dc.contributor.localIdA04219-
dc.relation.journalcodeJ01720-
dc.identifier.eissn1535-3907-
dc.identifier.pmid34766501-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acs.jproteome.1c00805-
dc.subject.keywordCA-19-9-
dc.subject.keywordComB-CAN-
dc.subject.keywordPDAC-
dc.subject.keywordcomplement factor B-
dc.subject.keywordearly detection-
dc.subject.keywordpancreatic cancer-
dc.subject.keywordtumor promotion-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.affiliatedAuthor강창무-
dc.contributor.affiliatedAuthor김호근-
dc.contributor.affiliatedAuthor이충근-
dc.contributor.affiliatedAuthor최혜진-
dc.citation.volume20-
dc.citation.number12-
dc.citation.startPage5315-
dc.citation.endPage5328-
dc.identifier.bibliographicCitationJOURNAL OF PROTEOME RESEARCH, Vol.20(12) : 5315-5328, 2021-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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