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K-RAS Acts as a Critical Regulator of CD44 to Promote the Invasiveness and Stemness of GBM in Response to Ionizing Radiation

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dc.contributor.author강석구-
dc.date.accessioned2021-12-28T17:51:47Z-
dc.date.available2021-12-28T17:51:47Z-
dc.date.issued2021-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187305-
dc.description.abstractRadiation therapy is a current standard-of-care treatment and is used widely for GBM patients. However, radiation therapy still remains a significant barrier to getting a successful outcome due to the therapeutic resistance and tumor recurrence. Understanding the underlying mechanisms of this resistance and recurrence would provide an efficient approach for improving the therapy for GBM treatment. Here, we identified a regulatory mechanism of CD44 which induces infiltration and mesenchymal shift of GBM. Ionizing radiation (IR)-induced K-RAS/ERK signaling activation elevates CD44 expression through downregulation of miR-202 and miR-185 expression. High expression of CD44 promotes SRC activation to induce cancer stemness and EMT features of GBM cells. In this study, we demonstrate that the K-RAS/ERK/CD44 axis is a key mechanism in regulating mesenchymal shift of GBM cells after irradiation. These findings suggest that blocking the K-RAS activation or CD44 expression could provide an efficient way for GBM treatment.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBrain Neoplasms / metabolism-
dc.subject.MESHBrain Neoplasms / mortality-
dc.subject.MESHBrain Neoplasms / pathology*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Movement / radiation effects-
dc.subject.MESHDown-Regulation / drug effects-
dc.subject.MESHExtracellular Signal-Regulated MAP Kinases / metabolism-
dc.subject.MESHGlioblastoma / metabolism-
dc.subject.MESHGlioblastoma / mortality-
dc.subject.MESHGlioblastoma / pathology*-
dc.subject.MESHHumans-
dc.subject.MESHHyaluronan Receptors / antagonists & inhibitors-
dc.subject.MESHHyaluronan Receptors / genetics-
dc.subject.MESHHyaluronan Receptors / metabolism*-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMicroRNAs / metabolism-
dc.subject.MESHProto-Oncogene Proteins p21(ras) / genetics-
dc.subject.MESHProto-Oncogene Proteins p21(ras) / metabolism*-
dc.subject.MESHRNA Interference-
dc.subject.MESHRNA, Small Interfering / metabolism-
dc.subject.MESHRadiation, Ionizing*-
dc.subject.MESHSignal Transduction / radiation effects*-
dc.titleK-RAS Acts as a Critical Regulator of CD44 to Promote the Invasiveness and Stemness of GBM in Response to Ionizing Radiation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorYi Zhao-
dc.contributor.googleauthorJae-Hyeok Kang-
dc.contributor.googleauthorKi-Chun Yoo-
dc.contributor.googleauthorSeok-Gu Kang-
dc.contributor.googleauthorHae-June Lee-
dc.contributor.googleauthorSu-Jae Lee-
dc.identifier.doi10.3390/ijms222010923-
dc.contributor.localIdA00036-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid34681583-
dc.subject.keywordCD44-
dc.subject.keywordK-RAS-
dc.subject.keywordglioblastoma (GBM)-
dc.subject.keywordionizing radiation-
dc.contributor.alternativeNameKang, Seok Gu-
dc.contributor.affiliatedAuthor강석구-
dc.citation.volume22-
dc.citation.number20-
dc.citation.startPage10923-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(20) : 10923, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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