Cited 0 times in
Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구자승 | - |
dc.contributor.author | 김혜민 | - |
dc.date.accessioned | 2021-12-28T17:50:56Z | - |
dc.date.available | 2021-12-28T17:50:56Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1015-2008 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187296 | - |
dc.description.abstract | Purpose: The aim of this study was to investigate the expression patterns of glucose metabolism-related proteins and their clinicopathologic implications in adrenal cortical neoplasms (ACN) and pheochromocytoma (PCC). Methods: Immunohistochemical staining was performed to evaluate glucose metabolism-related proteins (GLUT1, CAIX, hexokinase II, G6PDH, PHGDH, and SHMT1) in 132 ACN cases (115 adrenal cortical adenoma [ACA] and 17 adrenal cortical carcinoma [ACC]) and 189 PCC cases. Results: Expression levels of GLUT1 in tumor cells ([T]; p < 0.001), GLUT1 in stromal cells ([S]; p < 0.001), G6PDH (p < 0.001), and SHMT1 (p = 0.002) were higher in ACN than in PCC. GLUT1 (T; p = 0.045) and PHGDH (p = 0.043) levels were higher in ACC than in ACA. In a univariate analysis of ACN, GLUT1 (T; p = 0.017), CAIX (S; p = 0.003), and PHGDH (p = 0.009) levels were correlated with a shorter overall survival (OS). GLUT1 (T; p = 0.001) and PHGDH (p < 0.001) were related to a shorter OS in PCC. GLUT1 (T) positivity (p = 0.043) in ACN predicted a poor OS in a multivariate Cox analysis. In PCC, high GAPP score (p = 0.026), GLUT1 (T; p = 0.002), and PHGDH (p < 0.001) were independent prognostic factors for poor OS. Conclusions: The adrenal gland tumors ACN and PCC had different expression patterns of glucose metabolism-related proteins (GLUT1, G6PDH, and SHMT1), with higher expression levels in ACN than in PCC. GLUT1 and PHGDH were significant prognostic factors in these adrenal neoplasms. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | S. Karger | - |
dc.relation.isPartOf | PATHOBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Eun Kyung Kim | - |
dc.contributor.googleauthor | Hye Min Kim | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1159/000518208 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A04553 | - |
dc.relation.journalcode | J02470 | - |
dc.identifier.eissn | 1423-0291 | - |
dc.identifier.pmid | 34518477 | - |
dc.identifier.url | https://www.karger.com/Article/Abstract/518208 | - |
dc.subject.keyword | Adrenal cortical adenoma | - |
dc.subject.keyword | Adrenal cortical carcinoma | - |
dc.subject.keyword | Glucose metabolism | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Pheochromocytoma | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.contributor.affiliatedAuthor | 김혜민 | - |
dc.citation.volume | 88 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 424 | - |
dc.citation.endPage | 433 | - |
dc.identifier.bibliographicCitation | PATHOBIOLOGY, Vol.88(6) : 424-433, 2021-11 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.