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Association between the transtubular potassium gradient and progression of chronic kidney disease: results from KNOW-CKD
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 주영수 | - |
dc.contributor.author | 최규헌 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2021-12-28T17:48:41Z | - |
dc.date.available | 2021-12-28T17:48:41Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1121-8428 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187279 | - |
dc.description.abstract | Background: The transtubular potassium gradient which reflects potassium secretion by the kidney through the cortical collecting duct, has not yet been tested as a surrogate marker of kidney function decline. Here, we investigate the relationship between the transtubular potassium gradient and chronic kidney disease (CKD) progression. Methods: We studied 1672 patients from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort. The transtubular potassium gradient was calculated using a standard equation. The study endpoint was CKD progression, defined as a composite of a ≥ 50% decrease in estimated glomerular filtration rate (eGFR) from baseline values or end-stage kidney disease. Results: During a median follow-up of 4.1 years (7149 person-years), 441 participants reached the endpoint. In cause-specific competing risk analysis, the highest tertile was associated with a significantly lower risk of an adverse kidney outcome compared with the lowest tertile [hazard ratio (HR), 0.73; 95% confidence interval (CI), 0.55-0.97]. When the transtubular potassium gradient was treated as a continuous variable, an increase of 1 in the transtubular potassium gradient was associated with a 6% lower risk of CKD progression (95% CI, 0.90-0.99). This association was particularly evident in patients with an eGFR ≥ 45 mL/min/1.73 m2. A time-updated transtubular potassium gradient model showed similar results. The predictive performance of the transtubular potassium gradient was significantly less than that of the eGFR, but similar to that of proteinuria, serum bicarbonate, and urine osmolality. Conclusions: A higher transtubular potassium gradient is associated with a significantly lower risk of CKD progression, suggesting that it may offer insights into the prognosis of CKD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | JOURNAL OF NEPHROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association between the transtubular potassium gradient and progression of chronic kidney disease: results from KNOW-CKD | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seon Yeong Lee | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Young Su Joo | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Joongyub Lee | - |
dc.contributor.googleauthor | Wookyung Chung | - |
dc.contributor.googleauthor | Yong-Soo Kim | - |
dc.contributor.googleauthor | Soo Wan Kim | - |
dc.contributor.googleauthor | Kook-Hwan Oh | - |
dc.contributor.googleauthor | Curie Ahn | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Kyu Hun Choi | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.identifier.doi | 10.1007/s40620-021-01019-9 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A03956 | - |
dc.contributor.localId | A04043 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J01616 | - |
dc.identifier.eissn | 1724-6059 | - |
dc.identifier.pmid | 33755931 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs40620-021-01019-9 | - |
dc.subject.keyword | CKD progression | - |
dc.subject.keyword | Transtubular potassium gradient (TTKG) | - |
dc.subject.keyword | Urinary potassium excretion | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 주영수 | - |
dc.contributor.affiliatedAuthor | 최규헌 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2063 | - |
dc.citation.endPage | 2072 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEPHROLOGY, Vol.34(6) : 2063-2072, 2021-12 | - |
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