0 389

Cited 18 times in

Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts

DC Field Value Language
dc.contributor.author윤영섭-
dc.contributor.author이민구-
dc.date.accessioned2021-12-28T17:48:14Z-
dc.date.available2021-12-28T17:48:14Z-
dc.date.issued2021-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187275-
dc.description.abstractFibroblasts can be directly reprogrammed into cardiomyocytes, endothelial cells or smooth muscle cells. Here we report the reprogramming of mouse tail-tip fibroblasts simultaneously into cells resembling these three cell types using the microRNA mimic miR-208b-3p, ascorbic acid and bone morphogenetic protein 4, as well as the formation of tissue-like structures formed by the directly reprogrammed cells. Implantation of the formed cardiovascular tissue into the infarcted hearts of mice led to the migration of reprogrammed cells to the injured tissue, reducing regional cardiac strain and improving cardiac function. The migrated endothelial cells and smooth muscle cells contributed to vessel formation, and the migrated cardiomyocytes, which initially displayed immature characteristics, became mature over time and formed gap junctions with host cardiomyocytes. Direct reprogramming of somatic cells to make cardiac tissue may aid the development of applications in cell therapy, disease modelling and drug discovery for cardiovascular diseases.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherMacmillan Publishers Limited-
dc.relation.isPartOfNATURE BIOMEDICAL ENGINEERING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHAscorbic Acid / pharmacology-
dc.subject.MESHBone Morphogenetic Protein 4 / pharmacology-
dc.subject.MESHCellular Reprogramming / drug effects-
dc.subject.MESHEndothelial Cells / cytology-
dc.subject.MESHEndothelial Cells / metabolism-
dc.subject.MESHEndothelial Cells / transplantation*-
dc.subject.MESHFibroblasts / cytology-
dc.subject.MESHFibroblasts / metabolism-
dc.subject.MESHGap Junctions / physiology-
dc.subject.MESHHeart / physiology*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMicroRNAs / metabolism-
dc.subject.MESHMyocardial Infarction / therapy*-
dc.subject.MESHMyocardium / cytology-
dc.subject.MESHMyocardium / metabolism-
dc.subject.MESHMyocardium / pathology-
dc.subject.MESHMyocytes, Smooth Muscle / cytology-
dc.subject.MESHMyocytes, Smooth Muscle / metabolism-
dc.subject.MESHMyocytes, Smooth Muscle / transplantation*-
dc.subject.MESHMyosin Heavy Chains / genetics-
dc.subject.MESHMyosin Heavy Chains / metabolism-
dc.subject.MESHNeovascularization, Physiologic-
dc.subject.MESHRegeneration*-
dc.subject.MESHTranscriptome-
dc.titleRegeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorJaeyeaon Cho-
dc.contributor.googleauthorSangsung Kim-
dc.contributor.googleauthorHyein Lee-
dc.contributor.googleauthorWoongchan Rah-
dc.contributor.googleauthorHee Cheol Cho-
dc.contributor.googleauthorNam Kyun Kim-
dc.contributor.googleauthorSeongho Bae-
dc.contributor.googleauthorDong Hoon Shin-
dc.contributor.googleauthorMin Goo Lee-
dc.contributor.googleauthorIn-Hyun Park-
dc.contributor.googleauthorYoshiaki Tanaka-
dc.contributor.googleauthorEric Shin-
dc.contributor.googleauthorHong Yi-
dc.contributor.googleauthorJi Woong Han-
dc.contributor.googleauthorPatrick Tae Joon Hwang-
dc.contributor.googleauthorHo-Wook Jun-
dc.contributor.googleauthorHun-Jun Park-
dc.contributor.googleauthorKyuwon Cho-
dc.contributor.googleauthorSang Wook Lee-
dc.contributor.googleauthorJae Kyung Jung-
dc.contributor.googleauthorRebecca D Levit-
dc.contributor.googleauthorMark A Sussman-
dc.contributor.googleauthorRichard P Harvey-
dc.contributor.googleauthorYoung-Sup Yoon-
dc.identifier.doi10.1038/s41551-021-00783-0-
dc.contributor.localIdA02579-
dc.relation.journalcodeJ03462-
dc.identifier.eissn2157-846X-
dc.identifier.pmid34426676-
dc.identifier.urlhttps://www.nature.com/articles/s41551-021-00783-0-
dc.contributor.alternativeNameYoon, Young Sup-
dc.contributor.affiliatedAuthor윤영섭-
dc.citation.volume5-
dc.citation.number8-
dc.citation.startPage880-
dc.citation.endPage896-
dc.identifier.bibliographicCitationNATURE BIOMEDICAL ENGINEERING, Vol.5(8) : 880-896, 2021-08-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.