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Tumor Glucose Metabolism and Its Heterogeneity on F-18 FDG PET/CT Provide Better Prognostication in Nonmetastatic Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma
DC Field | Value | Language |
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dc.contributor.author | 강원준 | - |
dc.contributor.author | 김소영 | - |
dc.contributor.author | 정용휴 | - |
dc.contributor.author | 조호진 | - |
dc.date.accessioned | 2021-12-28T17:47:43Z | - |
dc.date.available | 2021-12-28T17:47:43Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187270 | - |
dc.description.abstract | Background: We aimed to evaluate the prognostic role of metabolic parameters on baseline F-18 fluorodeoxyglucose (FDG) PET/CT in patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC). Methods: We retrospectively reviewed patients who were diagnosed with nonmetastatic HPV-related OPSCC using the 8th TNM staging system from 2010 to 2015 and underwent baseline F-18 FDG PET/CT. Tumor SUVmax to liver SUVmean ratio (SUVmax-TLR), metabolic tumor volume (MTV), tumor total lesion glycolysis to liver SUVmean ratio (TLG-TLR), and coefficient of variation (CV) of the primary tumor were measured. Patients were primarily treated with surgery or radiotherapy. Endpoints were progression-free survival (PFS) and overall survival (OS). Results: Ninety consecutive patients (male, 72; female, 18) were enrolled. They were followed up for a median of 77.4 months (interquartile range, 48.4-106.4). Sixteen patients progressed, and 13 died. Multivariate analysis revealed that patients with advanced age, overall stage, and higher SUVmax-TLR or CV had poorer PFS and OS. Conclusion: Higher SUVmax-TLR and CV of the primary tumor on baseline F-18 FDG PET/CT were associated with poorer PFS and OS in patients with nonmetastatic HPV-related OPSCC. Further study is warranted to address the possible implications of F-18 FDG PET/CT on treatment de-intensification in these patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Tumor Glucose Metabolism and Its Heterogeneity on F-18 FDG PET/CT Provide Better Prognostication in Nonmetastatic Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학교실) | - |
dc.contributor.googleauthor | Hojin Cho | - |
dc.contributor.googleauthor | Soyoung Kim | - |
dc.contributor.googleauthor | Kwanhyeong Jo | - |
dc.contributor.googleauthor | Yong Hyu Jeong | - |
dc.contributor.googleauthor | Won Jun Kang | - |
dc.identifier.doi | 10.3390/cancers13215538 | - |
dc.contributor.localId | A00062 | - |
dc.contributor.localId | A05460 | - |
dc.contributor.localId | A05554 | - |
dc.contributor.localId | A03941 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 34771700 | - |
dc.subject.keyword | DG | - |
dc.subject.keyword | PET/CT | - |
dc.subject.keyword | oropharyngeal carcinoma | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Kang, Won Jun | - |
dc.contributor.affiliatedAuthor | 강원준 | - |
dc.contributor.affiliatedAuthor | 김소영 | - |
dc.contributor.affiliatedAuthor | 정용휴 | - |
dc.contributor.affiliatedAuthor | 조호진 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 5538 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.13(21) : 5538, 2021-11 | - |
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