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Prevalence of Osteopenia in Drug-Naive Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Monocentric Study

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dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author유병우-
dc.contributor.author이상원-
dc.contributor.author정승민-
dc.date.accessioned2021-12-28T17:46:32Z-
dc.date.available2021-12-28T17:46:32Z-
dc.date.issued2021-12-
dc.identifier.issn1076-1608-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187262-
dc.description.abstractObjectives: To examine the bone mineral density and prevalence of osteoporosis and osteopenia in glucocorticoid- and immunosuppressive drug-naive patients younger than 55 years with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Methods: This was a cross-sectional study. We reviewed the medical records of 35 AAV patients and 35 age-, sex-, and body mass index (BMI)-matched control subjects. We collected clinical data such as AAV-related variables and conventional risk factors for osteoporosis and assessed bone mineral density and the prevalence of osteoporosis and osteopenia in both groups. Categorical and continuous variables were compared between the 2 groups using the χ2 or Fisher exact test and Mann-Whitney U test, respectively. Multivariate logistic regression analysis was used to calculate the odds ratio (OR). Results: There were no statistically significant differences between the demographical data of AAV patients and control subjects. Patients with AAV showed significantly higher frequencies of conventional risk factors for osteoporosis than the control subjects, except for hyperthyroidism. Osteopenia was found more commonly in AAV patients than in control subjects (57.1% vs. 31.4%, p = 0.030). In the univariate logistic regression analysis, BMI (OR, 0.813) and AAV (OR, 2.620) were associated with osteopenia in all participants. In the multivariate analysis, both BMI and AAV were associated with osteopenia, but this was not statistically significant. In contrast, when analyzing AAV patients only, neither conventional risk factors nor AAV-related variables were associated with the prevalence of osteopenia. Conclusions: Antineutrophil cytoplasmic antibody-associated vasculitis and BMI were both associated with osteopenia.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfJCR-JOURNAL OF CLINICAL RHEUMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / diagnosis-
dc.subject.MESHAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / epidemiology-
dc.subject.MESHAntibodies, Antineutrophil Cytoplasmic-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHHumans-
dc.subject.MESHOsteoporosis* / diagnosis-
dc.subject.MESHOsteoporosis* / epidemiology-
dc.subject.MESHPharmaceutical Preparations*-
dc.subject.MESHPrevalence-
dc.titlePrevalence of Osteopenia in Drug-Naive Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Monocentric Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorByung-Woo Yoo-
dc.contributor.googleauthorSeung Min Jung-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorSang-Won Lee-
dc.identifier.doi10.1097/RHU.0000000000001413-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02467-
dc.contributor.localIdA02824-
dc.contributor.localIdA05179-
dc.relation.journalcodeJ01215-
dc.identifier.eissn1536-7355-
dc.identifier.pmid32530864-
dc.identifier.urlhttps://journals.lww.com/jclinrheum/Abstract/2021/12000/Prevalence_of_Osteopenia_in_Drug_Naive_Patients.13.aspx-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor유병우-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor정승민-
dc.citation.volume27-
dc.citation.number8-
dc.citation.startPagee330-
dc.citation.endPagee335-
dc.identifier.bibliographicCitationJCR-JOURNAL OF CLINICAL RHEUMATOLOGY, Vol.27(8) : e330-e335, 2021-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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