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Association between depression and the risk of Alzheimer's disease using the Korean National Health Insurance Service-Elderly Cohort
DC Field | Value | Language |
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dc.contributor.author | 김유석 | - |
dc.contributor.author | 박은철 | - |
dc.contributor.author | 장성인 | - |
dc.date.accessioned | 2021-12-28T17:45:54Z | - |
dc.date.available | 2021-12-28T17:45:54Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187256 | - |
dc.description.abstract | In this cohort study, we assessed the association between depression and the risk of Alzheimer's disease from data obtained from the 2002 to 2013 Korean National Health Insurance Service-Elderly Cohort Database, which accounts for 10% of the South Korean population aged > 60 years. A total 518,466 patients were included in the analysis and followed up, unless they were excluded due to death or migration. Patients who sought treatment for depression or dementia within 1 year of the washout period and who were diagnosed with dementia within the 1-year period of the diagnosis of depression were excluded from the study. The risk of dementia was analysed using Cox proportional hazards models. Patients with a history of depression during the follow-up period were at a higher risk of Alzheimer's disease than those without a history of depression (HR 3.35, CI 3.27-3.42). The severe-depression group exhibited the highest risk of Alzheimer's disease (HR 4.41, CI 4.04-4.81), while the mild-depression group exhibited a relatively lower risk of Alzheimer's disease (HR 3.31, CI 3.16-3.47). The risk of Alzheimer's disease was associated with depression history and an increased severity of depression increased the risk of Alzheimer's disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association between depression and the risk of Alzheimer's disease using the Korean National Health Insurance Service-Elderly Cohort | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Hyunkyu Kim | - |
dc.contributor.googleauthor | Wonjeong Jeong | - |
dc.contributor.googleauthor | Junhyun Kwon | - |
dc.contributor.googleauthor | Youseok Kim | - |
dc.contributor.googleauthor | Eun-Cheol Park | - |
dc.contributor.googleauthor | Sung-In Jang | - |
dc.identifier.doi | 10.1038/s41598-021-02201-6 | - |
dc.contributor.localId | A00784 | - |
dc.contributor.localId | A01618 | - |
dc.contributor.localId | A03439 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 34799679 | - |
dc.contributor.alternativeName | Kim, You Seok | - |
dc.contributor.affiliatedAuthor | 김유석 | - |
dc.contributor.affiliatedAuthor | 박은철 | - |
dc.contributor.affiliatedAuthor | 장성인 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 22591 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.11(1) : 22591, 2021-11 | - |
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