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Reparative System Arising from CCR2(+) Monocyte Conversion Attenuates Neuroinflammation Following Ischemic Stroke

Authors
 Joohyun Park  ;  Jong Youl Kim  ;  Yu Rim Kim  ;  Meiying Huang  ;  Ji Young Chang  ;  A Young Sim  ;  Hosung Jung  ;  Won Taek Lee  ;  Young-Min Hyun  ;  Jong Eun Lee 
Citation
 TRANSLATIONAL STROKE RESEARCH, Vol.12(5) : 879-893, 2021-10 
Journal Title
TRANSLATIONAL STROKE RESEARCH
ISSN
 1868-4483 
Issue Date
2021-10
Keywords
CCR2 ; CX3CR1 ; Macrophages ; Monocytes conversion ; Neuroinflammation ischemic stroke
Abstract
Monocytes recruitment from the blood to inflamed tissues following ischemic stroke is an important immune response to wound healing and tissue repair. Mouse monocytes can be endogenously divided into two distinct populations: pro-inflammatory or classical monocytes that express CCR2highCX3CR1low and circulate in blood, and anti-inflammatory or non-classical monocytes that express CCR2lowCX3CR1high and patrol locally. In this study of transgenic mice with functional CX3CR1GFP/+ or CX3CR1GFP/+-CCR2RFP/+, we found that CCR2highCX3CR1low monocytes recruited to the injured brain were cytokine-dependently converted into CCR2lowCX3CR1high macrophages, especially under the influence of IL-4 and IL-13, thereby attenuating the neuroinflammation following sterile ischemic stroke. The overall data suggest that (1) the regulation of monocyte-switching is one of the ultimate reparative strategies in ischemic stroke, and (2) the adaptation of monocytes in a locally inflamed milieu is vital to alleviating the effects of ischemic stroke through innate immunity.
Files in This Item:
T202105368.pdf Download
DOI
10.1007/s12975-020-00878-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youl(김종열) ORCID logo https://orcid.org/0000-0002-8340-2894
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
Jung, Ho Sung(정호성) ORCID logo https://orcid.org/0000-0002-5059-8050
Hyun, Young-Min(현영민) ORCID logo https://orcid.org/0000-0002-0567-2039
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187249
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