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Serum progranulin as a predictive marker for high activity of antineutrophil cytoplasmic antibody-associated vasculitis
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 송정식 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 이은주 | - |
dc.contributor.author | 표정윤 | - |
dc.date.accessioned | 2021-12-28T17:43:46Z | - |
dc.date.available | 2021-12-28T17:43:46Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 0887-8013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187243 | - |
dc.description.abstract | Background: This study investigated whether serum progranulin could act as a predictive marker for high disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Methods: Fifty-eight AAV patients were included in this study. Clinical and laboratory data were obtained at blood collection. The Short-Form 36-Item Health Survey Physical and Mental Component Summaries (SF-36 PCS and SF-36 MCS), Birmingham Vasculitis activity score (BVAS), Five-Factor Score (FFS), and Vasculitis Damage Index (VDI) were assessed as AAV-specific indices. Whole blood was collected and serum samples were isolated and stored at -80°C. Serum progranulin concentration was quantified by ELISA kits. Results: The median age of patients was 63.0 years (19 men). The median BVAS was 11.0, and the median serum progranulin level was 49.0 ng/ml. Serum progranulin was significantly correlated with BVAS, FFS, erythrocyte sedimentation rate, C-reactive protein level, SF-36 PCS, haemoglobin, and serum albumin. Severe AAV was arbitrarily defined as the highest tertile of BVAS (BVAS ≥16). When the cut-offs of serum progranulin were set as 55.16 ng/ml and 43.01 ng/ml for severe AAV, AAV patients with serum progranulin ≥55.16 and 43.01 ng/ml had significantly higher risks of severe AAV than those without (relative risk (RR) 4.167 and 4.524, respectively). Conclusions: Progranulin might play an anti-inflammatory role in AAV pathogenesis and serum progranulin could be used as a predictive marker for high activity of AAV. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wiley-Liss, Inc. | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL LABORATORY ANALYSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Serum progranulin as a predictive marker for high activity of antineutrophil cytoplasmic antibody-associated vasculitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Taejun Yoon | - |
dc.contributor.googleauthor | Lucy Eunju Lee | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Jung Yoon Pyo | - |
dc.contributor.googleauthor | Jason Jungsik Song | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.identifier.doi | 10.1002/jcla.24048 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A05935 | - |
dc.contributor.localId | A04244 | - |
dc.relation.journalcode | J01323 | - |
dc.identifier.eissn | 1098-2825 | - |
dc.identifier.pmid | 34626000 | - |
dc.subject.keyword | Birmingham vasculitis activity score | - |
dc.subject.keyword | antineutrophil cytoplasmic antibody | - |
dc.subject.keyword | progranulin | - |
dc.subject.keyword | vasculitis | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 송정식 | - |
dc.contributor.affiliatedAuthor | 안성수 | - |
dc.contributor.affiliatedAuthor | 이상원 | - |
dc.contributor.affiliatedAuthor | 이은주 | - |
dc.contributor.affiliatedAuthor | 표정윤 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | e24048 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL LABORATORY ANALYSIS, Vol.35(11) : e24048, 2021-11 | - |
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