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Minimally Invasive Versus Open Pancreatectomy for Right-Sided and Left-Sided G1/G2 Nonfunctioning Pancreatic Neuroendocrine Tumors: A Multicenter Matched Analysis with an Inverse Probability of Treatment-Weighting Method

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dc.contributor.author강창무-
dc.contributor.author박준성-
dc.contributor.author황호경-
dc.date.accessioned2021-12-28T17:38:36Z-
dc.date.available2021-12-28T17:38:36Z-
dc.date.issued2021-11-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187200-
dc.description.abstractBackground: Limited evidence exists for the safety and oncologic efficacy of minimally invasive surgery (MIS) for nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) according to tumor location. This study aimed to compare the surgical outcomes of MIS and open surgery (OS) for right- or left-sided NF-PNETs. Methods: The study collected data on patients who underwent surgical resection (pancreatoduodenectomy, distal/total/central pancreatectomy, duodenum-preserving pancreas head resection, or enucleation) of a localized NF-PNET between January 2000 and July 2017 at 14 institutions. The inverse probability of treatment-weighting method with propensity scores was used for analysis. Results: The study enrolled 859 patients: 478 OS and 381 MIS patients. A matched analysis by tumor location showed no differences in resection margin, intraoperative blood loss, or complications between MIS and OS. However, MIS was associated with a longer operation time for right-sided tumors (393.3 vs 316.7 min; P < 0.001) and a shorter postoperative hospital stay for left-sided tumors (8.9 vs 12.9 days; P < 0.01). The MIS group was associated with significantly higher survival rates than the OS group for right- and left-sided tumors, but survival did not differ for the patients divided by tumor grade and location. Multivariable analysis showed that MIS did not affect survival for any tumor location. Conclusion: The short-term outcomes offered by MIS were comparable with those of OS except for a longer operation time for right-sided NF-PNETs. The oncologic outcomes were not compromised by MIS regardless of tumor location or grade. These findings suggest that MIS can be performed safely for selected patients with localized NF-PNETs.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHHumans-
dc.subject.MESHMinimally Invasive Surgical Procedures-
dc.subject.MESHNeuroendocrine Tumors* / surgery-
dc.subject.MESHPancreatectomy-
dc.subject.MESHPancreatic Neoplasms* / surgery-
dc.subject.MESHPancreaticoduodenectomy-
dc.subject.MESHPropensity Score-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titleMinimally Invasive Versus Open Pancreatectomy for Right-Sided and Left-Sided G1/G2 Nonfunctioning Pancreatic Neuroendocrine Tumors: A Multicenter Matched Analysis with an Inverse Probability of Treatment-Weighting Method-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorHo Kyoung Hwang-
dc.contributor.googleauthorKi Byung Song-
dc.contributor.googleauthorMinsu Park-
dc.contributor.googleauthorWooil Kwon-
dc.contributor.googleauthorJin-Young Jang-
dc.contributor.googleauthorJin Seok Heo-
dc.contributor.googleauthorDong Wook Choi-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorJoon Seong Park-
dc.contributor.googleauthorTae Ho Hong-
dc.contributor.googleauthorChol Kyoon Cho-
dc.contributor.googleauthorKeun Soo Ahn-
dc.contributor.googleauthorHuisong Lee-
dc.contributor.googleauthorSeung Eun Lee-
dc.contributor.googleauthorChi-Young Jeong-
dc.contributor.googleauthorYoung Hoon Roh-
dc.contributor.googleauthorHee Joon Kim-
dc.contributor.googleauthorDae Wook Hwang-
dc.contributor.googleauthorSong Cheol Kim-
dc.contributor.googleauthorHo-Seong Han-
dc.contributor.googleauthorYoo-Seok Yoon-
dc.identifier.doi10.1245/s10434-021-10092-0-
dc.contributor.localIdA00088-
dc.contributor.localIdA01672-
dc.contributor.localIdA04497-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid33969463-
dc.identifier.urlhttps://link.springer.com/article/10.1245%2Fs10434-021-10092-0-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.affiliatedAuthor강창무-
dc.contributor.affiliatedAuthor박준성-
dc.contributor.affiliatedAuthor황호경-
dc.citation.volume28-
dc.citation.number12-
dc.citation.startPage7742-
dc.citation.endPage7758-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.28(12) : 7742-7758, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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